MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy

Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning...

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Autores principales:	Maria Cristina Rapanotti, Elisa Cugini, Marzia Nuccetelli, Alessandro Terrinoni, Cosimo Di Raimondo, Paolo Lombardo, Gaetana Costanza, Terenzio Cosio, Piero Rossi, Augusto Orlandi, Elena Campione, Sergio Bernardini, Marcel Blot-Chabaud, Luca Bianchi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MCAM/MUC18/CD146 soluble CD146 liquid biopsy circulating melanoma cells (CMCs) gene-expression panel Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7a30d42c08c843d5a4a9c43fc41a85f4
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spelling	oai:doaj.org-article:7a30d42c08c843d5a4a9c43fc41a85f42021-11-25T17:56:28ZMCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy10.3390/ijms2222124161422-00671661-6596https://doaj.org/article/7a30d42c08c843d5a4a9c43fc41a85f42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12416https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular “warning” marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments.Maria Cristina RapanottiElisa CuginiMarzia NuccetelliAlessandro TerrinoniCosimo Di RaimondoPaolo LombardoGaetana CostanzaTerenzio CosioPiero RossiAugusto OrlandiElena CampioneSergio BernardiniMarcel Blot-ChabaudLuca BianchiMDPI AGarticleMCAM/MUC18/CD146soluble CD146liquid biopsycirculating melanoma cells (CMCs)gene-expression panelBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12416, p 12416 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MCAM/MUC18/CD146 soluble CD146 liquid biopsy circulating melanoma cells (CMCs) gene-expression panel Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	MCAM/MUC18/CD146 soluble CD146 liquid biopsy circulating melanoma cells (CMCs) gene-expression panel Biology (General) QH301-705.5 Chemistry QD1-999 Maria Cristina Rapanotti Elisa Cugini Marzia Nuccetelli Alessandro Terrinoni Cosimo Di Raimondo Paolo Lombardo Gaetana Costanza Terenzio Cosio Piero Rossi Augusto Orlandi Elena Campione Sergio Bernardini Marcel Blot-Chabaud Luca Bianchi MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
description	Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular “warning” marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments.
format	article
author	Maria Cristina Rapanotti Elisa Cugini Marzia Nuccetelli Alessandro Terrinoni Cosimo Di Raimondo Paolo Lombardo Gaetana Costanza Terenzio Cosio Piero Rossi Augusto Orlandi Elena Campione Sergio Bernardini Marcel Blot-Chabaud Luca Bianchi
author_facet	Maria Cristina Rapanotti Elisa Cugini Marzia Nuccetelli Alessandro Terrinoni Cosimo Di Raimondo Paolo Lombardo Gaetana Costanza Terenzio Cosio Piero Rossi Augusto Orlandi Elena Campione Sergio Bernardini Marcel Blot-Chabaud Luca Bianchi
author_sort	Maria Cristina Rapanotti
title	MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
title_short	MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
title_full	MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
title_fullStr	MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
title_full_unstemmed	MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
title_sort	mcam/muc18/cd146 as a multifaceted warning marker of melanoma progression in liquid biopsy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a30d42c08c843d5a4a9c43fc41a85f4
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MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy

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