Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration

Enterovirus, like the majority of RNA viruses, evolves to survive the changeable environments by a variety of strategies. Here, we showed that HY12 virus evolved to alter its characteristics and pathogenicity by employing a non-synonymous mutation. Analyses of 5′UTR, VP1 and VP2 gene sequences revea...

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Autores principales:	Xiaoran Chang, Lisai Zhu, Junying Hu, Qun Zhang, Fuhui Zhang, Qian Lin, Xiaochun Gai, Xinping Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HY12 enterovirus EV-E quasispecies evolution pattern mutation selection Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7a3332343ca34b1b89eb0ba72716e389
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spelling	oai:doaj.org-article:7a3332343ca34b1b89eb0ba72716e3892021-11-25T19:13:03ZUnveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration10.3390/v131121741999-4915https://doaj.org/article/7a3332343ca34b1b89eb0ba72716e3892021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2174https://doaj.org/toc/1999-4915Enterovirus, like the majority of RNA viruses, evolves to survive the changeable environments by a variety of strategies. Here, we showed that HY12 virus evolved to alter its characteristics and pathogenicity by employing a non-synonymous mutation. Analyses of 5′UTR, VP1 and VP2 gene sequences revealed the existence of HY12 virus in an array of mutants defined as quasispecies. The determination of diversity and complexity showed that the mutation rate and complexity of HY12 virus quasispecies increased, while the proportion of HY12 VP1 and VP2 consensus (master) sequences decreased with increasing passages. Synonymous mutation and non-synonymous mutation analysis displayed a positive selection for HY12 quasispecies evolution. A comparison of HY12 virus in different passages demonstrated that HY12 virus altered its characteristic, phenotype, and pathogenicity via non-synonymous mutation. These findings revealed the evolution pattern for HY12 virus, and the alteration of HY12 virus characteristics and pathogenicity by mutation.Xiaoran ChangLisai ZhuJunying HuQun ZhangFuhui ZhangQian LinXiaochun GaiXinping WangMDPI AGarticleHY12 enterovirusEV-Equasispeciesevolution patternmutationselectionMicrobiologyQR1-502ENViruses, Vol 13, Iss 2174, p 2174 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HY12 enterovirus EV-E quasispecies evolution pattern mutation selection Microbiology QR1-502
spellingShingle	HY12 enterovirus EV-E quasispecies evolution pattern mutation selection Microbiology QR1-502 Xiaoran Chang Lisai Zhu Junying Hu Qun Zhang Fuhui Zhang Qian Lin Xiaochun Gai Xinping Wang Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
description	Enterovirus, like the majority of RNA viruses, evolves to survive the changeable environments by a variety of strategies. Here, we showed that HY12 virus evolved to alter its characteristics and pathogenicity by employing a non-synonymous mutation. Analyses of 5′UTR, VP1 and VP2 gene sequences revealed the existence of HY12 virus in an array of mutants defined as quasispecies. The determination of diversity and complexity showed that the mutation rate and complexity of HY12 virus quasispecies increased, while the proportion of HY12 VP1 and VP2 consensus (master) sequences decreased with increasing passages. Synonymous mutation and non-synonymous mutation analysis displayed a positive selection for HY12 quasispecies evolution. A comparison of HY12 virus in different passages demonstrated that HY12 virus altered its characteristic, phenotype, and pathogenicity via non-synonymous mutation. These findings revealed the evolution pattern for HY12 virus, and the alteration of HY12 virus characteristics and pathogenicity by mutation.
format	article
author	Xiaoran Chang Lisai Zhu Junying Hu Qun Zhang Fuhui Zhang Qian Lin Xiaochun Gai Xinping Wang
author_facet	Xiaoran Chang Lisai Zhu Junying Hu Qun Zhang Fuhui Zhang Qian Lin Xiaochun Gai Xinping Wang
author_sort	Xiaoran Chang
title	Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
title_short	Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
title_full	Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
title_fullStr	Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
title_full_unstemmed	Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration
title_sort	unveiling of evolution pattern for hy12 enterovirus quasispecies and pathogenicity alteration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a3332343ca34b1b89eb0ba72716e389
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_version_	1718410165223424000

Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration

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