A synergetic effect of BARD1 mutations on tumorigenesis

Mutations in the BARD1 gene have been identified as risk factors in breast and ovarian cancers. Here the authors reveal a synergetic effect between the occurance of two cis mutations in the BARD1 gene affecting the cellular DNA damage response and consequently tumorigenesis.

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Autores principales:	Wenjing Li, Xiaoyang Gu, Chunhong Liu, Yanyan Shi, Pan Wang, Na Zhang, Rui Wu, Liang Leng, Bingteng Xie, Chen Song, Mo Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a37045af7a44a0f82d41c601a782661
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spelling	oai:doaj.org-article:7a37045af7a44a0f82d41c601a7826612021-12-02T10:59:14ZA synergetic effect of BARD1 mutations on tumorigenesis10.1038/s41467-021-21519-32041-1723https://doaj.org/article/7a37045af7a44a0f82d41c601a7826612021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21519-3https://doaj.org/toc/2041-1723Mutations in the BARD1 gene have been identified as risk factors in breast and ovarian cancers. Here the authors reveal a synergetic effect between the occurance of two cis mutations in the BARD1 gene affecting the cellular DNA damage response and consequently tumorigenesis.Wenjing LiXiaoyang GuChunhong LiuYanyan ShiPan WangNa ZhangRui WuLiang LengBingteng XieChen SongMo LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjing Li Xiaoyang Gu Chunhong Liu Yanyan Shi Pan Wang Na Zhang Rui Wu Liang Leng Bingteng Xie Chen Song Mo Li A synergetic effect of BARD1 mutations on tumorigenesis
description	Mutations in the BARD1 gene have been identified as risk factors in breast and ovarian cancers. Here the authors reveal a synergetic effect between the occurance of two cis mutations in the BARD1 gene affecting the cellular DNA damage response and consequently tumorigenesis.
format	article
author	Wenjing Li Xiaoyang Gu Chunhong Liu Yanyan Shi Pan Wang Na Zhang Rui Wu Liang Leng Bingteng Xie Chen Song Mo Li
author_facet	Wenjing Li Xiaoyang Gu Chunhong Liu Yanyan Shi Pan Wang Na Zhang Rui Wu Liang Leng Bingteng Xie Chen Song Mo Li
author_sort	Wenjing Li
title	A synergetic effect of BARD1 mutations on tumorigenesis
title_short	A synergetic effect of BARD1 mutations on tumorigenesis
title_full	A synergetic effect of BARD1 mutations on tumorigenesis
title_fullStr	A synergetic effect of BARD1 mutations on tumorigenesis
title_full_unstemmed	A synergetic effect of BARD1 mutations on tumorigenesis
title_sort	synergetic effect of bard1 mutations on tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a37045af7a44a0f82d41c601a782661
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A synergetic effect of BARD1 mutations on tumorigenesis

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