Structural basis of the activation of type 1 insulin-like growth factor receptor

The activation mechanism of type 1 insulin-like growth factor receptor (IGF1R) is not fully understood. Here, the authors determine the cryo-EM structure of full-length, IGF1-bound IGF1R in the active conformation, providing insights into how IGF1 triggers receptor activation.

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Autores principales:	Jie Li, Eunhee Choi, Hongtao Yu, Xiao-chen Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a376ae3400f4c8b83371371a1d4709a
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spelling	oai:doaj.org-article:7a376ae3400f4c8b83371371a1d4709a2021-12-02T17:32:24ZStructural basis of the activation of type 1 insulin-like growth factor receptor10.1038/s41467-019-12564-02041-1723https://doaj.org/article/7a376ae3400f4c8b83371371a1d4709a2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12564-0https://doaj.org/toc/2041-1723The activation mechanism of type 1 insulin-like growth factor receptor (IGF1R) is not fully understood. Here, the authors determine the cryo-EM structure of full-length, IGF1-bound IGF1R in the active conformation, providing insights into how IGF1 triggers receptor activation.Jie LiEunhee ChoiHongtao YuXiao-chen BaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Li Eunhee Choi Hongtao Yu Xiao-chen Bai Structural basis of the activation of type 1 insulin-like growth factor receptor
description	The activation mechanism of type 1 insulin-like growth factor receptor (IGF1R) is not fully understood. Here, the authors determine the cryo-EM structure of full-length, IGF1-bound IGF1R in the active conformation, providing insights into how IGF1 triggers receptor activation.
format	article
author	Jie Li Eunhee Choi Hongtao Yu Xiao-chen Bai
author_facet	Jie Li Eunhee Choi Hongtao Yu Xiao-chen Bai
author_sort	Jie Li
title	Structural basis of the activation of type 1 insulin-like growth factor receptor
title_short	Structural basis of the activation of type 1 insulin-like growth factor receptor
title_full	Structural basis of the activation of type 1 insulin-like growth factor receptor
title_fullStr	Structural basis of the activation of type 1 insulin-like growth factor receptor
title_full_unstemmed	Structural basis of the activation of type 1 insulin-like growth factor receptor
title_sort	structural basis of the activation of type 1 insulin-like growth factor receptor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a376ae3400f4c8b83371371a1d4709a
work_keys_str_mv	AT jieli structuralbasisoftheactivationoftype1insulinlikegrowthfactorreceptor AT eunheechoi structuralbasisoftheactivationoftype1insulinlikegrowthfactorreceptor AT hongtaoyu structuralbasisoftheactivationoftype1insulinlikegrowthfactorreceptor AT xiaochenbai structuralbasisoftheactivationoftype1insulinlikegrowthfactorreceptor
_version_	1718380316483125248

Structural basis of the activation of type 1 insulin-like growth factor receptor

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