Structural basis of the activation of type 1 insulin-like growth factor receptor

The activation mechanism of type 1 insulin-like growth factor receptor (IGF1R) is not fully understood. Here, the authors determine the cryo-EM structure of full-length, IGF1-bound IGF1R in the active conformation, providing insights into how IGF1 triggers receptor activation.

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Detalles Bibliográficos
Autores principales: Jie Li, Eunhee Choi, Hongtao Yu, Xiao-chen Bai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7a376ae3400f4c8b83371371a1d4709a
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