The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.

Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in...

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Autores principales:	Renata Curciarello, Alison Steele, Dianne Cooper, Thomas T MacDonald, Laurens Kruidenier, Takahiro Kudo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a39030ed43f4da9ab93777fc01dd609
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spelling	oai:doaj.org-article:7a39030ed43f4da9ab93777fc01dd6092021-11-25T05:59:53ZThe role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.1932-620310.1371/journal.pone.0107933https://doaj.org/article/7a39030ed43f4da9ab93777fc01dd6092014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107933https://doaj.org/toc/1932-6203Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.Renata CurciarelloAlison SteeleDianne CooperThomas T MacDonaldLaurens KruidenierTakahiro KudoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107933 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renata Curciarello Alison Steele Dianne Cooper Thomas T MacDonald Laurens Kruidenier Takahiro Kudo The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
description	Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
format	article
author	Renata Curciarello Alison Steele Dianne Cooper Thomas T MacDonald Laurens Kruidenier Takahiro Kudo
author_facet	Renata Curciarello Alison Steele Dianne Cooper Thomas T MacDonald Laurens Kruidenier Takahiro Kudo
author_sort	Renata Curciarello
title	The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
title_short	The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
title_full	The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
title_fullStr	The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
title_full_unstemmed	The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.
title_sort	role of galectin-1 and galectin-3 in the mucosal immune response to citrobacter rodentium infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7a39030ed43f4da9ab93777fc01dd609
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The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.

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