Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling

Layla Kamareddine,1– 3 Crystal M Ghantous,4 Soumaya Allouch,5 Sarah A Al-Ashmar,2,5 Gulsen Anlar,2,5 Surya Kannan,2,5 Laiche Djouhri,2,5 Hesham M Korashy,2,6 Abdelali Agouni,2,6 Asad Zeidan2,5 1Department Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Bio...

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Autores principales:	Kamareddine L, Ghantous CM, Allouch S, Al-Ashmar SA, Anlar G, Kannan S, Djouhri L, Korashy HM, Agouni A, Zeidan A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	inflammation autophagy leptin adiponectin cardiac cells Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7a397d51e9b64134b96f8c3142a435c1
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spelling	oai:doaj.org-article:7a397d51e9b64134b96f8c3142a435c12021-12-02T17:57:53ZBetween Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling1178-7031https://doaj.org/article/7a397d51e9b64134b96f8c3142a435c12021-10-01T00:00:00Zhttps://www.dovepress.com/between-inflammation-and-autophagy-the-role-of-leptin-adiponectin-axis-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Layla Kamareddine,1– 3 Crystal M Ghantous,4 Soumaya Allouch,5 Sarah A Al-Ashmar,2,5 Gulsen Anlar,2,5 Surya Kannan,2,5 Laiche Djouhri,2,5 Hesham M Korashy,2,6 Abdelali Agouni,2,6 Asad Zeidan2,5 1Department Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar; 3Biomedical Research Center, Qatar University, Doha, Qatar; 4Department of Nursing and Health Sciences, Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Keserwan, Lebanon; 5Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar; 6Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, QatarCorrespondence: Asad ZeidanDepartment of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, QatarEmail a.zeidan@qu.edu.qaAbstract: Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long-term exposure. Autophagy, a cellular catabolic process that was originally considered as a mechanism of cell death in response to detrimental stimuli, is thought to be one of the main mechanisms that controls cardiac remodeling and induces heart failure. Dysregulation of the adipokines leptin and adiponectin, which plays essential roles in lipid and glucose metabolism, and in the pathophysiology of the neuroendocrine and cardiovascular systems, has been shown to affect the autophagic response in the heart and to contribute to accelerate cardiac remodeling. The obesity-associated protein leptin is a pro-inflammatory, tumor-promoting adipocytokine whose elevated levels in obesity are associated with acute cardiovascular events, and obesity-related hypertension. Adiponectin exerts anti-inflammatory and anti-tumor effects, and its reduced levels in obesity correlate with the pathogenesis of obesity-associated cardiovascular diseases. Leptin- and adiponectin-induced changes in autophagic flux have been linked to cardiac remodeling and heart failure. In this review, we describe the different molecular mechanisms of hyperleptinemia- and hypoadiponectinemia-mediated pathogenesis of cardiac remodeling and the involvement of autophagy in this process. A better understanding of the roles of leptin, adiponectin, and autophagy in cardiac functions and remodeling, and the exact signal transduction pathways by which they contribute to cardiac diseases may well lead to discovery of new therapeutic agents for the treatment of cardiovascular remodeling.Keywords: inflammation, autophagy, leptin, adiponectin, cardiac cellsKamareddine LGhantous CMAllouch SAl-Ashmar SAAnlar GKannan SDjouhri LKorashy HMAgouni AZeidan ADove Medical Pressarticleinflammationautophagyleptinadiponectincardiac cellsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5349-5365 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation autophagy leptin adiponectin cardiac cells Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	inflammation autophagy leptin adiponectin cardiac cells Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Kamareddine L Ghantous CM Allouch S Al-Ashmar SA Anlar G Kannan S Djouhri L Korashy HM Agouni A Zeidan A Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
description	Layla Kamareddine,1– 3 Crystal M Ghantous,4 Soumaya Allouch,5 Sarah A Al-Ashmar,2,5 Gulsen Anlar,2,5 Surya Kannan,2,5 Laiche Djouhri,2,5 Hesham M Korashy,2,6 Abdelali Agouni,2,6 Asad Zeidan2,5 1Department Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar; 3Biomedical Research Center, Qatar University, Doha, Qatar; 4Department of Nursing and Health Sciences, Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Keserwan, Lebanon; 5Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar; 6Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, QatarCorrespondence: Asad ZeidanDepartment of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, QatarEmail a.zeidan@qu.edu.qaAbstract: Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long-term exposure. Autophagy, a cellular catabolic process that was originally considered as a mechanism of cell death in response to detrimental stimuli, is thought to be one of the main mechanisms that controls cardiac remodeling and induces heart failure. Dysregulation of the adipokines leptin and adiponectin, which plays essential roles in lipid and glucose metabolism, and in the pathophysiology of the neuroendocrine and cardiovascular systems, has been shown to affect the autophagic response in the heart and to contribute to accelerate cardiac remodeling. The obesity-associated protein leptin is a pro-inflammatory, tumor-promoting adipocytokine whose elevated levels in obesity are associated with acute cardiovascular events, and obesity-related hypertension. Adiponectin exerts anti-inflammatory and anti-tumor effects, and its reduced levels in obesity correlate with the pathogenesis of obesity-associated cardiovascular diseases. Leptin- and adiponectin-induced changes in autophagic flux have been linked to cardiac remodeling and heart failure. In this review, we describe the different molecular mechanisms of hyperleptinemia- and hypoadiponectinemia-mediated pathogenesis of cardiac remodeling and the involvement of autophagy in this process. A better understanding of the roles of leptin, adiponectin, and autophagy in cardiac functions and remodeling, and the exact signal transduction pathways by which they contribute to cardiac diseases may well lead to discovery of new therapeutic agents for the treatment of cardiovascular remodeling.Keywords: inflammation, autophagy, leptin, adiponectin, cardiac cells
format	article
author	Kamareddine L Ghantous CM Allouch S Al-Ashmar SA Anlar G Kannan S Djouhri L Korashy HM Agouni A Zeidan A
author_facet	Kamareddine L Ghantous CM Allouch S Al-Ashmar SA Anlar G Kannan S Djouhri L Korashy HM Agouni A Zeidan A
author_sort	Kamareddine L
title	Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
title_short	Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
title_full	Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
title_fullStr	Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
title_full_unstemmed	Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
title_sort	between inflammation and autophagy: the role of leptin-adiponectin axis in cardiac remodeling
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7a397d51e9b64134b96f8c3142a435c1
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Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling

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