Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice

Background and Objective: The side effects of anti-nociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydroalcoholic extract of Thymus vulgaris (TV) on neurogenic and inflammatory pain in formalin test in mice. Methods: 40 male albino m...

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Autores principales:	AA Taherian, A Rashidi Pour, M Arefi, A Vafaei, M Emami Abarghoei, H Sadeghi, M Jarrahi, H Miladi Gorji
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2005
Materias:	thymus vulgaris neurogenic and inflammatory pain formalin test Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7a3c680b8d24422dabf319df36f471ea
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spelling	oai:doaj.org-article:7a3c680b8d24422dabf319df36f471ea2021-11-10T09:14:32ZAssessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice1561-41072251-7170https://doaj.org/article/7a3c680b8d24422dabf319df36f471ea2005-04-01T00:00:00Zhttp://jbums.org/article-1-2633-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: The side effects of anti-nociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydroalcoholic extract of Thymus vulgaris (TV) on neurogenic and inflammatory pain in formalin test in mice. Methods: 40 male albino mice (20-30 gr) were used. TV (100, 500 mg/kg) as extract and saline were injected 30 mine before formalin test. Indexes for evaluation were duration of licking and foot elevation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25 µl) in paw. Findings: Results indicated that TV has analgesic effect in both doses (P<0.01), and higher dose (500 mg) was more effective. Conclusion: Findings showed that hydroalcoholic extract of TV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation.AA TaherianA Rashidi PourM ArefiA VafaeiM Emami AbarghoeiH SadeghiM JarrahiH Miladi GorjiBabol University of Medical Sciencesarticlethymus vulgarisneurogenic and inflammatory painformalin testMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 2, Pp 24-29 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thymus vulgaris neurogenic and inflammatory pain formalin test Medicine R Medicine (General) R5-920
spellingShingle	thymus vulgaris neurogenic and inflammatory pain formalin test Medicine R Medicine (General) R5-920 AA Taherian A Rashidi Pour M Arefi A Vafaei M Emami Abarghoei H Sadeghi M Jarrahi H Miladi Gorji Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
description	Background and Objective: The side effects of anti-nociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydroalcoholic extract of Thymus vulgaris (TV) on neurogenic and inflammatory pain in formalin test in mice. Methods: 40 male albino mice (20-30 gr) were used. TV (100, 500 mg/kg) as extract and saline were injected 30 mine before formalin test. Indexes for evaluation were duration of licking and foot elevation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25 µl) in paw. Findings: Results indicated that TV has analgesic effect in both doses (P<0.01), and higher dose (500 mg) was more effective. Conclusion: Findings showed that hydroalcoholic extract of TV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation.
format	article
author	AA Taherian A Rashidi Pour M Arefi A Vafaei M Emami Abarghoei H Sadeghi M Jarrahi H Miladi Gorji
author_facet	AA Taherian A Rashidi Pour M Arefi A Vafaei M Emami Abarghoei H Sadeghi M Jarrahi H Miladi Gorji
author_sort	AA Taherian
title	Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
title_short	Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
title_full	Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
title_fullStr	Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
title_full_unstemmed	Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice
title_sort	assessment of hydroalcoholic extract of thymus vulgaris on neurogenic and inflammatory pain in mice
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/7a3c680b8d24422dabf319df36f471ea
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Assessment of hydroalcoholic extract of Thymus Vulgaris on neurogenic and inflammatory pain in mice

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