Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’

Osteosarcoma is a genetically complex cancer, thus there are increasing efforts to identify biomarkers and regulators within the epigenome that can better predict patient outcomes and provide new therapeutic targets. In this commentary, we have evaluated the work of Peng and colleagues on the identi...

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Autores principales:	Kaniz Fatema, Jared J. Barrott
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7a3fa71b2c214294a590be81317067ce
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spelling	oai:doaj.org-article:7a3fa71b2c214294a590be81317067ce2021-11-20T05:05:14ZCircling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’1936-523310.1016/j.tranon.2021.101271https://doaj.org/article/7a3fa71b2c214294a590be81317067ce2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S193652332100262Xhttps://doaj.org/toc/1936-5233Osteosarcoma is a genetically complex cancer, thus there are increasing efforts to identify biomarkers and regulators within the epigenome that can better predict patient outcomes and provide new therapeutic targets. In this commentary, we have evaluated the work of Peng and colleagues on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma. We provide the context of how novel it is to demonstrate the anti-tumor functions of APOA1 and not just correlative gene expression with patient outcome. We further postulate why some studies involving circRNAs in osteosarcoma contradict one another. We conclude that the study performed by Peng and colleagues was performed with enough rigor to give confidence that circ_0088212 is a bona fide tumor suppressor in osteosarcoma.Kaniz FatemaJared J. BarrottElsevierarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101271- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kaniz Fatema Jared J. Barrott Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
description	Osteosarcoma is a genetically complex cancer, thus there are increasing efforts to identify biomarkers and regulators within the epigenome that can better predict patient outcomes and provide new therapeutic targets. In this commentary, we have evaluated the work of Peng and colleagues on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma. We provide the context of how novel it is to demonstrate the anti-tumor functions of APOA1 and not just correlative gene expression with patient outcome. We further postulate why some studies involving circRNAs in osteosarcoma contradict one another. We conclude that the study performed by Peng and colleagues was performed with enough rigor to give confidence that circ_0088212 is a bona fide tumor suppressor in osteosarcoma.
format	article
author	Kaniz Fatema Jared J. Barrott
author_facet	Kaniz Fatema Jared J. Barrott
author_sort	Kaniz Fatema
title	Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
title_short	Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
title_full	Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
title_fullStr	Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
title_full_unstemmed	Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
title_sort	circling back to epigenetic regulation in osteosarcoma: comment on ‘hsa_circ_0088212-mediated mir-520h/apoa1 axis inhibits the osteosarcoma progression’ by ‘ hao peng’
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/7a3fa71b2c214294a590be81317067ce
work_keys_str_mv	AT kanizfatema circlingbacktoepigeneticregulationinosteosarcomacommentonhsacirc0088212mediatedmir520hapoa1axisinhibitstheosteosarcomaprogressionbyhaopeng AT jaredjbarrott circlingbacktoepigeneticregulationinosteosarcomacommentonhsacirc0088212mediatedmir520hapoa1axisinhibitstheosteosarcomaprogressionbyhaopeng
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Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’

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