Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris).
The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species...
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Public Library of Science (PLoS)
2014
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oai:doaj.org-article:7a400d03ee7146c0919e8f4e88dcda5f2021-11-18T08:37:47ZOxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris).1932-620310.1371/journal.pone.0083993https://doaj.org/article/7a400d03ee7146c0919e8f4e88dcda5f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454713/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species to model human social interactions. Previous research indicates that dogs are eligible models for behavioral genetic research, as well. Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (-212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5' and 3' UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. Dogs' behavior traits have been estimated in a newly developed test series consisting of five episodes: Greeting by a stranger, Separation from the owner, Problem solving, Threatening approach, Hiding of the owner. Buccal samples were collected and DNA was isolated using standard protocols. SNPs in the 3' and 5' UTR regions were analyzed by polymerase chain reaction based techniques followed by subsequent electrophoresis analysis. The gene-behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system.Anna KisMelinda BenceGabriella LakatosEnikő PergelBorbála TurcsánJolanda PluijmakersJudit VasZsuzsanna ElekIldikó BrúderLevente FöldiMária Sasvári-SzékelyAdám MiklósiZsolt RónaiEnikő KubinyiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e83993 (2014) |
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Medicine R Science Q |
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Medicine R Science Q Anna Kis Melinda Bence Gabriella Lakatos Enikő Pergel Borbála Turcsán Jolanda Pluijmakers Judit Vas Zsuzsanna Elek Ildikó Brúder Levente Földi Mária Sasvári-Székely Adám Miklósi Zsolt Rónai Enikő Kubinyi Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| description |
The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species to model human social interactions. Previous research indicates that dogs are eligible models for behavioral genetic research, as well. Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (-212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5' and 3' UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. Dogs' behavior traits have been estimated in a newly developed test series consisting of five episodes: Greeting by a stranger, Separation from the owner, Problem solving, Threatening approach, Hiding of the owner. Buccal samples were collected and DNA was isolated using standard protocols. SNPs in the 3' and 5' UTR regions were analyzed by polymerase chain reaction based techniques followed by subsequent electrophoresis analysis. The gene-behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system. |
| format |
article |
| author |
Anna Kis Melinda Bence Gabriella Lakatos Enikő Pergel Borbála Turcsán Jolanda Pluijmakers Judit Vas Zsuzsanna Elek Ildikó Brúder Levente Földi Mária Sasvári-Székely Adám Miklósi Zsolt Rónai Enikő Kubinyi |
| author_facet |
Anna Kis Melinda Bence Gabriella Lakatos Enikő Pergel Borbála Turcsán Jolanda Pluijmakers Judit Vas Zsuzsanna Elek Ildikó Brúder Levente Földi Mária Sasvári-Székely Adám Miklósi Zsolt Rónai Enikő Kubinyi |
| author_sort |
Anna Kis |
| title |
Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| title_short |
Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| title_full |
Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| title_fullStr |
Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| title_full_unstemmed |
Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). |
| title_sort |
oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (canis familiaris). |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/7a400d03ee7146c0919e8f4e88dcda5f |
| work_keys_str_mv |
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