Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type

Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eulàlia Solà-Porta, Dolores Redondo-Pachón, Carlos Arias-Cabrales, Diego Navazo, Anna Buxeda, Carla Burballa, Marta Crespo, Montserrat García-Retortillo, Julio Pascual, María José Pérez-Sáez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	donor after circulatory death early hypertransaminasemia kidney transplantation transaminases Medicine R
Acceso en línea:	https://doaj.org/article/7a4be361c9744bb2bc3df7fa2a9703d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a4be361c9744bb2bc3df7fa2a9703d7
record_format	dspace
spelling	oai:doaj.org-article:7a4be361c9744bb2bc3df7fa2a9703d72021-11-11T17:46:57ZEarly Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type10.3390/jcm102151682077-0383https://doaj.org/article/7a4be361c9744bb2bc3df7fa2a9703d72021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5168https://doaj.org/toc/2077-0383Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzing the increase in serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) during the first three months post-KT in 151 recipients who received thymoglobulin as induction therapy, either from brain-death donors (DBD, <i>n</i> = 75), controlled circulatory death donors (cDCD, <i>n</i> = 33), or uncontrolled DCD (uDCD, <i>n</i> = 43). Eighty-five KT recipients from DBD who received basiliximab were included as controls. From KT recipients who received thymoglobulin, 33.6/43.4% presented with an increase in AST/ALT at 72 h post-KT, respectively. Regarding donor type, the percentage of recipients who experienced 72 h post-KT hypertransaminasemia was higher in uDCD group (65.1/83.7% vs. 20.3/26% in DBD and 20.7/27.6% in cDCD, <i>p</i> < 0.001). Within the control group, 9.4/12.9% of patients presented with AST/ALT elevation. One month after transplant, AST/ALT values returned to baseline in all groups. The multivariate analysis showed that uDCD recipients had 6- to 12-fold higher risk of developing early post-KT hypertransaminasemia. Early post-KT hypertransaminasemia is a frequent and transient event related to the kidney donor type, being more frequent in uDCD recipients.Eulàlia Solà-PortaDolores Redondo-PachónCarlos Arias-CabralesDiego NavazoAnna BuxedaCarla BurballaMarta CrespoMontserrat García-RetortilloJulio PascualMaría José Pérez-SáezMDPI AGarticledonor after circulatory deathearlyhypertransaminasemiakidney transplantationtransaminasesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5168, p 5168 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	donor after circulatory death early hypertransaminasemia kidney transplantation transaminases Medicine R
spellingShingle	donor after circulatory death early hypertransaminasemia kidney transplantation transaminases Medicine R Eulàlia Solà-Porta Dolores Redondo-Pachón Carlos Arias-Cabrales Diego Navazo Anna Buxeda Carla Burballa Marta Crespo Montserrat García-Retortillo Julio Pascual María José Pérez-Sáez Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
description	Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzing the increase in serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) during the first three months post-KT in 151 recipients who received thymoglobulin as induction therapy, either from brain-death donors (DBD, <i>n</i> = 75), controlled circulatory death donors (cDCD, <i>n</i> = 33), or uncontrolled DCD (uDCD, <i>n</i> = 43). Eighty-five KT recipients from DBD who received basiliximab were included as controls. From KT recipients who received thymoglobulin, 33.6/43.4% presented with an increase in AST/ALT at 72 h post-KT, respectively. Regarding donor type, the percentage of recipients who experienced 72 h post-KT hypertransaminasemia was higher in uDCD group (65.1/83.7% vs. 20.3/26% in DBD and 20.7/27.6% in cDCD, <i>p</i> < 0.001). Within the control group, 9.4/12.9% of patients presented with AST/ALT elevation. One month after transplant, AST/ALT values returned to baseline in all groups. The multivariate analysis showed that uDCD recipients had 6- to 12-fold higher risk of developing early post-KT hypertransaminasemia. Early post-KT hypertransaminasemia is a frequent and transient event related to the kidney donor type, being more frequent in uDCD recipients.
format	article
author	Eulàlia Solà-Porta Dolores Redondo-Pachón Carlos Arias-Cabrales Diego Navazo Anna Buxeda Carla Burballa Marta Crespo Montserrat García-Retortillo Julio Pascual María José Pérez-Sáez
author_facet	Eulàlia Solà-Porta Dolores Redondo-Pachón Carlos Arias-Cabrales Diego Navazo Anna Buxeda Carla Burballa Marta Crespo Montserrat García-Retortillo Julio Pascual María José Pérez-Sáez
author_sort	Eulàlia Solà-Porta
title	Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
title_short	Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
title_full	Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
title_fullStr	Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
title_full_unstemmed	Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type
title_sort	early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a4be361c9744bb2bc3df7fa2a9703d7
work_keys_str_mv	AT eulaliasolaporta earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT doloresredondopachon earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT carlosariascabrales earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT diegonavazo earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT annabuxeda earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT carlaburballa earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT martacrespo earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT montserratgarciaretortillo earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT juliopascual earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype AT mariajoseperezsaez earlyhypertransaminasemiaafterkidneytransplantationsignificanceandevolutionaccordingtodonortype
_version_	1718432008817868800

Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type

Ejemplares similares