Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

Aim. To study the relationship between changes in the artery structure and function and peripheral lymphocyte telomere length in patients with type 2 diabetes mellitus (DM2). Materials and methods. A total of 50 patients with T2DM and without clinical manifestations of cardiovascular disease (CVD)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ekaterina Nailyevna Dudinskaya, Olga Nikolaevna Tkacheva, Marina Vladimirovna Shestakova, Natalya Vasilyevna Brailova, Irina Dmitrievna Strazhesko, Dariga Uaidinichna Akasheva, Olesya Yuryevna Isaykina, Maria Sergeevna Pokrovskaya, Natalya Viktorovna Sharashkina, Sergey Anatolyevich Boytsov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	telomere length vascular aging diabetes mellitus insulin resistance Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/7a4ce1e8bf4e461fb4e465fdc41df7f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a4ce1e8bf4e461fb4e465fdc41df7f0
record_format	dspace
spelling	oai:doaj.org-article:7a4ce1e8bf4e461fb4e465fdc41df7f02021-11-14T09:00:19ZTelomere length and vascular wall in patients with Type 2 Diabetes Mellitus2072-03512072-037810.14341/DM2014331-38https://doaj.org/article/7a4ce1e8bf4e461fb4e465fdc41df7f02014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6620https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the relationship between changes in the artery structure and function and peripheral lymphocyte telomere length in patients with type 2 diabetes mellitus (DM2). Materials and methods. A total of 50 patients with T2DM and without clinical manifestations of cardiovascular disease (CVD) were included in the study; the control group consisted of 49 people. The following tests were conducted for all study participants: carbohydrate metabolism evaluation, carotid artery duplex scan to measure intima?media complex thickness (IMT) and to determine the presence of atherosclerotic plaques, carotid?femoral pulse wave velocity (PWV) measurement and lymphocyte telomere length measurement. Results. The vascular changes were more pronounced in patients with T2DM than in controls. The telomeres were shorter in patients with T2DM than in those without diabetes (9.53?0.1 vs 9.86?0.1, p=0.033). The participants were divided according to the telomere length. Among patients with T2DM, there were significant differences in the condition of the vascular wall [PWV: 10.58?0.1 m/s in patients with ?long? telomeres and 15.08?1.3 m/s in patients with ?short? telomeres; IMT: 0.80?0.09 mm in patients with ?long? telomeres and 0.87?0.05 mm in patients with ?short? telomeres (p=0.024)]. There were no significant differences in the arterial structure between the patient and control groups with ?long? telomeres [PWV: 10.58?0.1 m/s vs 10.5?0.5 m/s (p=0.913); IMT: 0.080?0.09 mm vs 0.73?0.03 mm (p=0.12). However, there were significant differences in the vascular wall condition between the patient and control groups with ?short? telomeres [PWV: 15.08?1.3 m/s vs, 10.7?0.5 m/s (p=0.015); IMT: 0.87?0.1 vs 0.78?0.1 (p=0.03)]. Conclusions. The signs of vascular ageing were more pronounced in patients with T2DM than in controls. However, despite diabetes, vascular changes were minimal in patients with ?long? lymphocyte telomeres, comparable with the state of the vascular walls in healthy individuals. Thus, enhanced lymphocyte telomere length may have a protective effect on the vascular wall and may prevent damage from carbohydrate metabolism disorders.Ekaterina Nailyevna DudinskayaOlga Nikolaevna TkachevaMarina Vladimirovna ShestakovaNatalya Vasilyevna BrailovaIrina Dmitrievna StrazheskoDariga Uaidinichna AkashevaOlesya Yuryevna IsaykinaMaria Sergeevna PokrovskayaNatalya Viktorovna SharashkinaSergey Anatolyevich BoytsovEndocrinology Research Centrearticletelomere lengthvascular agingdiabetes mellitusinsulin resistanceNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 31-38 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	telomere length vascular aging diabetes mellitus insulin resistance Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	telomere length vascular aging diabetes mellitus insulin resistance Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Nailyevna Dudinskaya Olga Nikolaevna Tkacheva Marina Vladimirovna Shestakova Natalya Vasilyevna Brailova Irina Dmitrievna Strazhesko Dariga Uaidinichna Akasheva Olesya Yuryevna Isaykina Maria Sergeevna Pokrovskaya Natalya Viktorovna Sharashkina Sergey Anatolyevich Boytsov Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
description	Aim. To study the relationship between changes in the artery structure and function and peripheral lymphocyte telomere length in patients with type 2 diabetes mellitus (DM2). Materials and methods. A total of 50 patients with T2DM and without clinical manifestations of cardiovascular disease (CVD) were included in the study; the control group consisted of 49 people. The following tests were conducted for all study participants: carbohydrate metabolism evaluation, carotid artery duplex scan to measure intima?media complex thickness (IMT) and to determine the presence of atherosclerotic plaques, carotid?femoral pulse wave velocity (PWV) measurement and lymphocyte telomere length measurement. Results. The vascular changes were more pronounced in patients with T2DM than in controls. The telomeres were shorter in patients with T2DM than in those without diabetes (9.53?0.1 vs 9.86?0.1, p=0.033). The participants were divided according to the telomere length. Among patients with T2DM, there were significant differences in the condition of the vascular wall [PWV: 10.58?0.1 m/s in patients with ?long? telomeres and 15.08?1.3 m/s in patients with ?short? telomeres; IMT: 0.80?0.09 mm in patients with ?long? telomeres and 0.87?0.05 mm in patients with ?short? telomeres (p=0.024)]. There were no significant differences in the arterial structure between the patient and control groups with ?long? telomeres [PWV: 10.58?0.1 m/s vs 10.5?0.5 m/s (p=0.913); IMT: 0.080?0.09 mm vs 0.73?0.03 mm (p=0.12). However, there were significant differences in the vascular wall condition between the patient and control groups with ?short? telomeres [PWV: 15.08?1.3 m/s vs, 10.7?0.5 m/s (p=0.015); IMT: 0.87?0.1 vs 0.78?0.1 (p=0.03)]. Conclusions. The signs of vascular ageing were more pronounced in patients with T2DM than in controls. However, despite diabetes, vascular changes were minimal in patients with ?long? lymphocyte telomeres, comparable with the state of the vascular walls in healthy individuals. Thus, enhanced lymphocyte telomere length may have a protective effect on the vascular wall and may prevent damage from carbohydrate metabolism disorders.
format	article
author	Ekaterina Nailyevna Dudinskaya Olga Nikolaevna Tkacheva Marina Vladimirovna Shestakova Natalya Vasilyevna Brailova Irina Dmitrievna Strazhesko Dariga Uaidinichna Akasheva Olesya Yuryevna Isaykina Maria Sergeevna Pokrovskaya Natalya Viktorovna Sharashkina Sergey Anatolyevich Boytsov
author_facet	Ekaterina Nailyevna Dudinskaya Olga Nikolaevna Tkacheva Marina Vladimirovna Shestakova Natalya Vasilyevna Brailova Irina Dmitrievna Strazhesko Dariga Uaidinichna Akasheva Olesya Yuryevna Isaykina Maria Sergeevna Pokrovskaya Natalya Viktorovna Sharashkina Sergey Anatolyevich Boytsov
author_sort	Ekaterina Nailyevna Dudinskaya
title	Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
title_short	Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
title_full	Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
title_fullStr	Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus
title_sort	telomere length and vascular wall in patients with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/7a4ce1e8bf4e461fb4e465fdc41df7f0
work_keys_str_mv	AT ekaterinanailyevnadudinskaya telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT olganikolaevnatkacheva telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT marinavladimirovnashestakova telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT natalyavasilyevnabrailova telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT irinadmitrievnastrazhesko telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT darigauaidinichnaakasheva telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT olesyayuryevnaisaykina telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT mariasergeevnapokrovskaya telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT natalyaviktorovnasharashkina telomerelengthandvascularwallinpatientswithtype2diabetesmellitus AT sergeyanatolyevichboytsov telomerelengthandvascularwallinpatientswithtype2diabetesmellitus
_version_	1718429540390273024

Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

Ejemplares similares