DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.

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Autores principales:	Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a4d1dd252984e45a207e050a9047c96
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spelling	oai:doaj.org-article:7a4d1dd252984e45a207e050a9047c962021-12-02T17:06:19ZDNA damage causes rapid accumulation of phosphoinositides for ATR signaling10.1038/s41467-017-01805-92041-1723https://doaj.org/article/7a4d1dd252984e45a207e050a9047c962017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01805-9https://doaj.org/toc/2041-1723Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.Yu-Hsiu WangAnushya HariharanGiulia BastianelloYusuke ToyamaG. V. ShivashankarMarco FoianiMichael P. SheetzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
description	Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.
format	article
author	Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz
author_facet	Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz
author_sort	Yu-Hsiu Wang
title	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_short	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_full	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_fullStr	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_full_unstemmed	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_sort	dna damage causes rapid accumulation of phosphoinositides for atr signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7a4d1dd252984e45a207e050a9047c96
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DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

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