Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate stress-induced depressive-like behaviors.

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Autores principales:	Sebastian P. Fernandez, Loïc Broussot, Fabio Marti, Thomas Contesse, Xavier Mouska, Mariano Soiza-Reilly, Hélène Marie, Philippe Faure, Jacques Barik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a4f1423a5b94bea8614630b86067284
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spelling	oai:doaj.org-article:7a4f1423a5b94bea8614630b860672842021-12-02T17:31:46ZMesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors10.1038/s41467-018-06809-72041-1723https://doaj.org/article/7a4f1423a5b94bea8614630b860672842018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06809-7https://doaj.org/toc/2041-1723Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate stress-induced depressive-like behaviors.Sebastian P. FernandezLoïc BroussotFabio MartiThomas ContesseXavier MouskaMariano Soiza-ReillyHélène MariePhilippe FaureJacques BarikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian P. Fernandez Loïc Broussot Fabio Marti Thomas Contesse Xavier Mouska Mariano Soiza-Reilly Hélène Marie Philippe Faure Jacques Barik Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
description	Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate stress-induced depressive-like behaviors.
format	article
author	Sebastian P. Fernandez Loïc Broussot Fabio Marti Thomas Contesse Xavier Mouska Mariano Soiza-Reilly Hélène Marie Philippe Faure Jacques Barik
author_facet	Sebastian P. Fernandez Loïc Broussot Fabio Marti Thomas Contesse Xavier Mouska Mariano Soiza-Reilly Hélène Marie Philippe Faure Jacques Barik
author_sort	Sebastian P. Fernandez
title	Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
title_short	Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
title_full	Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
title_fullStr	Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
title_full_unstemmed	Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
title_sort	mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7a4f1423a5b94bea8614630b86067284
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Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

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