Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Breast cancer heterogeneity and tumour evolutionary trajectories remain largely unknown among women of African ancestry. Here, the authors perform whole genome and transcriptome sequencing of Nigerian breast cancer patients and identify unique evolutionary phenomena.

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Autores principales: Naser Ansari-Pour, Yonglan Zheng, Toshio F. Yoshimatsu, Ayodele Sanni, Mustapha Ajani, Jean-Baptiste Reynier, Avraam Tapinos, Jason J. Pitt, Stefan Dentro, Anna Woodard, Padma Sheila Rajagopal, Dominic Fitzgerald, Andreas J. Gruber, Abayomi Odetunde, Abiodun Popoola, Adeyinka G. Falusi, Chinedum Peace Babalola, Temidayo Ogundiran, Nasiru Ibrahim, Jordi Barretina, Peter Van Loo, Mengjie Chen, Kevin P. White, Oladosu Ojengbede, John Obafunwa, Dezheng Huo, David C. Wedge, Olufunmilayo I. Olopade
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7a5145c553b747468c2fef56d8af5e4f
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spelling oai:doaj.org-article:7a5145c553b747468c2fef56d8af5e4f2021-11-28T12:32:19ZWhole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes10.1038/s41467-021-27079-w2041-1723https://doaj.org/article/7a5145c553b747468c2fef56d8af5e4f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27079-whttps://doaj.org/toc/2041-1723Breast cancer heterogeneity and tumour evolutionary trajectories remain largely unknown among women of African ancestry. Here, the authors perform whole genome and transcriptome sequencing of Nigerian breast cancer patients and identify unique evolutionary phenomena.Naser Ansari-PourYonglan ZhengToshio F. YoshimatsuAyodele SanniMustapha AjaniJean-Baptiste ReynierAvraam TapinosJason J. PittStefan DentroAnna WoodardPadma Sheila RajagopalDominic FitzgeraldAndreas J. GruberAbayomi OdetundeAbiodun PopoolaAdeyinka G. FalusiChinedum Peace BabalolaTemidayo OgundiranNasiru IbrahimJordi BarretinaPeter Van LooMengjie ChenKevin P. WhiteOladosu OjengbedeJohn ObafunwaDezheng HuoDavid C. WedgeOlufunmilayo I. OlopadeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Naser Ansari-Pour
Yonglan Zheng
Toshio F. Yoshimatsu
Ayodele Sanni
Mustapha Ajani
Jean-Baptiste Reynier
Avraam Tapinos
Jason J. Pitt
Stefan Dentro
Anna Woodard
Padma Sheila Rajagopal
Dominic Fitzgerald
Andreas J. Gruber
Abayomi Odetunde
Abiodun Popoola
Adeyinka G. Falusi
Chinedum Peace Babalola
Temidayo Ogundiran
Nasiru Ibrahim
Jordi Barretina
Peter Van Loo
Mengjie Chen
Kevin P. White
Oladosu Ojengbede
John Obafunwa
Dezheng Huo
David C. Wedge
Olufunmilayo I. Olopade
Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
description Breast cancer heterogeneity and tumour evolutionary trajectories remain largely unknown among women of African ancestry. Here, the authors perform whole genome and transcriptome sequencing of Nigerian breast cancer patients and identify unique evolutionary phenomena.
format article
author Naser Ansari-Pour
Yonglan Zheng
Toshio F. Yoshimatsu
Ayodele Sanni
Mustapha Ajani
Jean-Baptiste Reynier
Avraam Tapinos
Jason J. Pitt
Stefan Dentro
Anna Woodard
Padma Sheila Rajagopal
Dominic Fitzgerald
Andreas J. Gruber
Abayomi Odetunde
Abiodun Popoola
Adeyinka G. Falusi
Chinedum Peace Babalola
Temidayo Ogundiran
Nasiru Ibrahim
Jordi Barretina
Peter Van Loo
Mengjie Chen
Kevin P. White
Oladosu Ojengbede
John Obafunwa
Dezheng Huo
David C. Wedge
Olufunmilayo I. Olopade
author_facet Naser Ansari-Pour
Yonglan Zheng
Toshio F. Yoshimatsu
Ayodele Sanni
Mustapha Ajani
Jean-Baptiste Reynier
Avraam Tapinos
Jason J. Pitt
Stefan Dentro
Anna Woodard
Padma Sheila Rajagopal
Dominic Fitzgerald
Andreas J. Gruber
Abayomi Odetunde
Abiodun Popoola
Adeyinka G. Falusi
Chinedum Peace Babalola
Temidayo Ogundiran
Nasiru Ibrahim
Jordi Barretina
Peter Van Loo
Mengjie Chen
Kevin P. White
Oladosu Ojengbede
John Obafunwa
Dezheng Huo
David C. Wedge
Olufunmilayo I. Olopade
author_sort Naser Ansari-Pour
title Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
title_short Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
title_full Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
title_fullStr Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
title_full_unstemmed Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
title_sort whole-genome analysis of nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7a5145c553b747468c2fef56d8af5e4f
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