Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif

Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif

The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is bound.

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Detalles Bibliográficos
Autores principales: Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala, Benjamin P. Weissman, James R. Fuller, Xiaohong Tan, Tudor P. Constantin, Alan S. Waggoner, Marcel P. Bruchez, Bruce A. Armitage, Joseph A. Piccirilli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/7a5169ba2e1440eb811c773399e43486
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Descripción
Sumario:The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is bound.

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