SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

The SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Comparing 44 Sarbecovirus genomes provides a high-confidence protein-coding gene set. The study characterizes protein-level and nucleotide-level evolutionary constraints, and prioritizes functional mutations from t...

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Autores principales:	Irwin Jungreis, Rachel Sealfon, Manolis Kellis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a53523cf7404313919343c2f3a82916
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spelling	oai:doaj.org-article:7a53523cf7404313919343c2f3a829162021-12-02T16:58:20ZSARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes10.1038/s41467-021-22905-72041-1723https://doaj.org/article/7a53523cf7404313919343c2f3a829162021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22905-7https://doaj.org/toc/2041-1723The SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Comparing 44 Sarbecovirus genomes provides a high-confidence protein-coding gene set. The study characterizes protein-level and nucleotide-level evolutionary constraints, and prioritizes functional mutations from the ongoing COVID-19 pandemic.Irwin JungreisRachel SealfonManolis KellisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irwin Jungreis Rachel Sealfon Manolis Kellis SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
description	The SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Comparing 44 Sarbecovirus genomes provides a high-confidence protein-coding gene set. The study characterizes protein-level and nucleotide-level evolutionary constraints, and prioritizes functional mutations from the ongoing COVID-19 pandemic.
format	article
author	Irwin Jungreis Rachel Sealfon Manolis Kellis
author_facet	Irwin Jungreis Rachel Sealfon Manolis Kellis
author_sort	Irwin Jungreis
title	SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
title_short	SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
title_full	SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
title_fullStr	SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
title_full_unstemmed	SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
title_sort	sars-cov-2 gene content and covid-19 mutation impact by comparing 44 sarbecovirus genomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a53523cf7404313919343c2f3a82916
work_keys_str_mv	AT irwinjungreis sarscov2genecontentandcovid19mutationimpactbycomparing44sarbecovirusgenomes AT rachelsealfon sarscov2genecontentandcovid19mutationimpactbycomparing44sarbecovirusgenomes AT manoliskellis sarscov2genecontentandcovid19mutationimpactbycomparing44sarbecovirusgenomes
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SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

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