Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

Purpose The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors. Methods Twelve ovarian cancer survivors aged 33–61 years participated voluntarily in this study and were divided...

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Autores principales:	Jong-Kyun Lee, Yong-Seok Jee
Formato:	article
Lenguaje:	EN
Publicado:	Korean Continence Society 2021
Materias:	ovarian cancer resistance exercise adaptive immunocyte t cell Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/7a538afc1d6649fbb5e09268046fa503
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spelling	oai:doaj.org-article:7a538afc1d6649fbb5e09268046fa5032021-11-30T04:10:47ZEffect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study2093-47772093-693110.5213/inj.2142346.173https://doaj.org/article/7a538afc1d6649fbb5e09268046fa5032021-11-01T00:00:00Zhttp://www.einj.org/upload/pdf/inj-2142346-173.pdfhttps://doaj.org/toc/2093-4777https://doaj.org/toc/2093-6931Purpose The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors. Methods Twelve ovarian cancer survivors aged 33–61 years participated voluntarily in this study and were divided into control group (CG, n=6) and exercise group (EG, n=6). They underwent removal of ovarian cancer and received regular care for over one year. Resistance exercise was used as the intervention program conducted 4 days a week for 12 weeks. Skeletal muscle mass, muscle strength, and endurance were assessed at baseline and at week 12. Other dependent variables included adaptive immunocytes related to helper T (Th) cells and immunosuppressors (CD4+ and CD8+). Results After the intervention, skeletal muscle mass showed positive changes in EG com-pared to CG, although not significantly different. Muscle strength and endurance significantly increased in EG, while there was no significant change in CG. Th1, Th2, and Th1/Th2 ratio were significantly different between both groups. CD4+CD25+T cells and CD4+PD-1+T cells of EG were lower than those of CG. CD8+PD-1+T cells and CD8+TIGIT+T of EG were lower than those of CG. These results can be interpreted as the improved sensitivity of CD4+ and CD8+, which helps the secretion of myokines and cytokines, when cytotoxic substances are injected into the human body. Conclusions This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.Jong-Kyun LeeYong-Seok JeeKorean Continence Societyarticleovarian cancerresistance exerciseadaptive immunocytet cellDiseases of the genitourinary system. UrologyRC870-923ENInternational Neurourology Journal, Vol 25, Iss Suppl 2, Pp S96-105 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ovarian cancer resistance exercise adaptive immunocyte t cell Diseases of the genitourinary system. Urology RC870-923
spellingShingle	ovarian cancer resistance exercise adaptive immunocyte t cell Diseases of the genitourinary system. Urology RC870-923 Jong-Kyun Lee Yong-Seok Jee Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
description	Purpose The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors. Methods Twelve ovarian cancer survivors aged 33–61 years participated voluntarily in this study and were divided into control group (CG, n=6) and exercise group (EG, n=6). They underwent removal of ovarian cancer and received regular care for over one year. Resistance exercise was used as the intervention program conducted 4 days a week for 12 weeks. Skeletal muscle mass, muscle strength, and endurance were assessed at baseline and at week 12. Other dependent variables included adaptive immunocytes related to helper T (Th) cells and immunosuppressors (CD4+ and CD8+). Results After the intervention, skeletal muscle mass showed positive changes in EG com-pared to CG, although not significantly different. Muscle strength and endurance significantly increased in EG, while there was no significant change in CG. Th1, Th2, and Th1/Th2 ratio were significantly different between both groups. CD4+CD25+T cells and CD4+PD-1+T cells of EG were lower than those of CG. CD8+PD-1+T cells and CD8+TIGIT+T of EG were lower than those of CG. These results can be interpreted as the improved sensitivity of CD4+ and CD8+, which helps the secretion of myokines and cytokines, when cytotoxic substances are injected into the human body. Conclusions This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.
format	article
author	Jong-Kyun Lee Yong-Seok Jee
author_facet	Jong-Kyun Lee Yong-Seok Jee
author_sort	Jong-Kyun Lee
title	Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
title_short	Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
title_full	Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
title_fullStr	Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
title_full_unstemmed	Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study
title_sort	effect of resistance exercise on acquired immunocytes in cancer survivors: a pilot study
publisher	Korean Continence Society
publishDate	2021
url	https://doaj.org/article/7a538afc1d6649fbb5e09268046fa503
work_keys_str_mv	AT jongkyunlee effectofresistanceexerciseonacquiredimmunocytesincancersurvivorsapilotstudy AT yongseokjee effectofresistanceexerciseonacquiredimmunocytesincancersurvivorsapilotstudy
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Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

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