High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2

Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the sum...

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Autores principales:	Rita Jaafar, Celine Boschi, Sarah Aherfi, Audrey Bancod, Marion Le Bideau, Sophie Edouard, Philippe Colson, Henri Chahinian, Didier Raoult, Nouara Yahi, Jacques Fantini, Bernard La Scola
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS CoV2 variants antibodies COVID-19 vaccine heterogeneity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7a542ebc8b8d4521b2b7f6f54d66a65b
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spelling	oai:doaj.org-article:7a542ebc8b8d4521b2b7f6f54d66a65b2021-11-25T19:13:05ZHigh Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-210.3390/v131121771999-4915https://doaj.org/article/7a542ebc8b8d4521b2b7f6f54d66a65b2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2177https://doaj.org/toc/1999-4915Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies.Rita JaafarCeline BoschiSarah AherfiAudrey BancodMarion Le BideauSophie EdouardPhilippe ColsonHenri ChahinianDidier RaoultNouara YahiJacques FantiniBernard La ScolaMDPI AGarticleSARS CoV2variantsantibodiesCOVID-19vaccineheterogeneityMicrobiologyQR1-502ENViruses, Vol 13, Iss 2177, p 2177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS CoV2 variants antibodies COVID-19 vaccine heterogeneity Microbiology QR1-502
spellingShingle	SARS CoV2 variants antibodies COVID-19 vaccine heterogeneity Microbiology QR1-502 Rita Jaafar Celine Boschi Sarah Aherfi Audrey Bancod Marion Le Bideau Sophie Edouard Philippe Colson Henri Chahinian Didier Raoult Nouara Yahi Jacques Fantini Bernard La Scola High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
description	Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies.
format	article
author	Rita Jaafar Celine Boschi Sarah Aherfi Audrey Bancod Marion Le Bideau Sophie Edouard Philippe Colson Henri Chahinian Didier Raoult Nouara Yahi Jacques Fantini Bernard La Scola
author_facet	Rita Jaafar Celine Boschi Sarah Aherfi Audrey Bancod Marion Le Bideau Sophie Edouard Philippe Colson Henri Chahinian Didier Raoult Nouara Yahi Jacques Fantini Bernard La Scola
author_sort	Rita Jaafar
title	High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
title_short	High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
title_full	High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
title_fullStr	High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
title_full_unstemmed	High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
title_sort	high individual heterogeneity of neutralizing activities against the original strain and nine different variants of sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a542ebc8b8d4521b2b7f6f54d66a65b
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High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2

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