Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation

Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circuits. Here the authors show that transcription factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic and nigrostriatal dopaminergic pathways.

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Autores principales:	Audrey Chabrat, Guillaume Brisson, Hélène Doucet-Beaupré, Charleen Salesse, Marcos Schaan Profes, Axelle Dovonou, Cléophace Akitegetse, Julien Charest, Suzanne Lemstra, Daniel Côté, R. Jeroen Pasterkamp, Monica I. Abrudan, Emmanouil Metzakopian, Siew-Lan Ang, Martin Lévesque
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a54ea0e5bc64b529975e65373522976
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spelling	oai:doaj.org-article:7a54ea0e5bc64b529975e653735229762021-12-02T14:42:41ZTranscriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation10.1038/s41467-017-01042-02041-1723https://doaj.org/article/7a54ea0e5bc64b529975e653735229762017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01042-0https://doaj.org/toc/2041-1723Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circuits. Here the authors show that transcription factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic and nigrostriatal dopaminergic pathways.Audrey ChabratGuillaume BrissonHélène Doucet-BeaupréCharleen SalesseMarcos Schaan ProfesAxelle DovonouCléophace AkitegetseJulien CharestSuzanne LemstraDaniel CôtéR. Jeroen PasterkampMonica I. AbrudanEmmanouil MetzakopianSiew-Lan AngMartin LévesqueNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Audrey Chabrat Guillaume Brisson Hélène Doucet-Beaupré Charleen Salesse Marcos Schaan Profes Axelle Dovonou Cléophace Akitegetse Julien Charest Suzanne Lemstra Daniel Côté R. Jeroen Pasterkamp Monica I. Abrudan Emmanouil Metzakopian Siew-Lan Ang Martin Lévesque Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
description	Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circuits. Here the authors show that transcription factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic and nigrostriatal dopaminergic pathways.
format	article
author	Audrey Chabrat Guillaume Brisson Hélène Doucet-Beaupré Charleen Salesse Marcos Schaan Profes Axelle Dovonou Cléophace Akitegetse Julien Charest Suzanne Lemstra Daniel Côté R. Jeroen Pasterkamp Monica I. Abrudan Emmanouil Metzakopian Siew-Lan Ang Martin Lévesque
author_facet	Audrey Chabrat Guillaume Brisson Hélène Doucet-Beaupré Charleen Salesse Marcos Schaan Profes Axelle Dovonou Cléophace Akitegetse Julien Charest Suzanne Lemstra Daniel Côté R. Jeroen Pasterkamp Monica I. Abrudan Emmanouil Metzakopian Siew-Lan Ang Martin Lévesque
author_sort	Audrey Chabrat
title	Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
title_short	Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
title_full	Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
title_fullStr	Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
title_full_unstemmed	Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
title_sort	transcriptional repression of plxnc1 by lmx1a and lmx1b directs topographic dopaminergic circuit formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7a54ea0e5bc64b529975e65373522976
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Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation

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