Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.

Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.

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<h4>Purpose</h4>To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker.<h4>Methods</h4>35 patients with monocu...

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Autores principales: Bo-Een Hwang, Mirinae Kim, Young-Hoon Park
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/7a5ffd4f729648b6b9220bf8bfb5a711
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spelling oai:doaj.org-article:7a5ffd4f729648b6b9220bf8bfb5a7112021-12-02T20:16:40ZRole of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.1932-620310.1371/journal.pone.0258728https://doaj.org/article/7a5ffd4f729648b6b9220bf8bfb5a7112021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258728https://doaj.org/toc/1932-6203<h4>Purpose</h4>To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker.<h4>Methods</h4>35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT).<h4>Results</h4>The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05).<h4>Conclusions</h4>The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.Bo-Een HwangMirinae KimYoung-Hoon ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258728 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Bo-Een Hwang
Mirinae Kim
Young-Hoon Park
Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
description <h4>Purpose</h4>To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker.<h4>Methods</h4>35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT).<h4>Results</h4>The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05).<h4>Conclusions</h4>The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.
format article
author Bo-Een Hwang
Mirinae Kim
Young-Hoon Park
author_facet Bo-Een Hwang
Mirinae Kim
Young-Hoon Park
author_sort Bo-Een Hwang
title Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
title_short Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
title_full Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
title_fullStr Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
title_full_unstemmed Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema.
title_sort role of the choroidal vascularity index in branch retinal vein occlusion (brvo) with macular edema.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/7a5ffd4f729648b6b9220bf8bfb5a711
work_keys_str_mv AT boeenhwang roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema
AT mirinaekim roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema
AT younghoonpark roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema
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