Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

The human estrogen receptor alpha (hERα) is a hormone-responsive transcription factor. Here the authors combine small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling and show that multidomain hERα adopts an L-shaped boot-like architecture revealing a cross-ta...

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Autores principales:	Wei Huang, Yi Peng, Janna Kiselar, Xuan Zhao, Aljawharah Albaqami, Daniel Mendez, Yinghua Chen, Srinivas Chakravarthy, Sayan Gupta, Corie Ralston, Hung-Ying Kao, Mark R. Chance, Sichun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a63a8eb8ede415ebe1d5dce6fd54c97
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spelling	oai:doaj.org-article:7a63a8eb8ede415ebe1d5dce6fd54c972021-12-02T16:57:00ZMultidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains10.1038/s41467-018-06034-22041-1723https://doaj.org/article/7a63a8eb8ede415ebe1d5dce6fd54c972018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06034-2https://doaj.org/toc/2041-1723The human estrogen receptor alpha (hERα) is a hormone-responsive transcription factor. Here the authors combine small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling and show that multidomain hERα adopts an L-shaped boot-like architecture revealing a cross-talk between its DNA-binding domain and Ligand-binding domain.Wei HuangYi PengJanna KiselarXuan ZhaoAljawharah AlbaqamiDaniel MendezYinghua ChenSrinivas ChakravarthySayan GuptaCorie RalstonHung-Ying KaoMark R. ChanceSichun YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Huang Yi Peng Janna Kiselar Xuan Zhao Aljawharah Albaqami Daniel Mendez Yinghua Chen Srinivas Chakravarthy Sayan Gupta Corie Ralston Hung-Ying Kao Mark R. Chance Sichun Yang Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
description	The human estrogen receptor alpha (hERα) is a hormone-responsive transcription factor. Here the authors combine small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling and show that multidomain hERα adopts an L-shaped boot-like architecture revealing a cross-talk between its DNA-binding domain and Ligand-binding domain.
format	article
author	Wei Huang Yi Peng Janna Kiselar Xuan Zhao Aljawharah Albaqami Daniel Mendez Yinghua Chen Srinivas Chakravarthy Sayan Gupta Corie Ralston Hung-Ying Kao Mark R. Chance Sichun Yang
author_facet	Wei Huang Yi Peng Janna Kiselar Xuan Zhao Aljawharah Albaqami Daniel Mendez Yinghua Chen Srinivas Chakravarthy Sayan Gupta Corie Ralston Hung-Ying Kao Mark R. Chance Sichun Yang
author_sort	Wei Huang
title	Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
title_short	Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
title_full	Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
title_fullStr	Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
title_full_unstemmed	Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
title_sort	multidomain architecture of estrogen receptor reveals interfacial cross-talk between its dna-binding and ligand-binding domains
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7a63a8eb8ede415ebe1d5dce6fd54c97
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Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

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