PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to the K27M oncohistone.

Guardado en:

Detalles Bibliográficos
Autores principales:	Siddhant U. Jain, Truman J. Do, Peder J. Lund, Andrew Q. Rashoff, Katharine L. Diehl, Marcin Cieslik, Andrea Bajic, Nikoleta Juretic, Shriya Deshmukh, Sriram Venneti, Tom W. Muir, Benjamin A. Garcia, Nada Jabado, Peter W. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a64b34bead04eeeabaa7ea08c232938
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a64b34bead04eeeabaa7ea08c232938
record_format	dspace
spelling	oai:doaj.org-article:7a64b34bead04eeeabaa7ea08c2329382021-12-02T17:01:26ZPFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism10.1038/s41467-019-09981-62041-1723https://doaj.org/article/7a64b34bead04eeeabaa7ea08c2329382019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09981-6https://doaj.org/toc/2041-1723PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to the K27M oncohistone.Siddhant U. JainTruman J. DoPeder J. LundAndrew Q. RashoffKatharine L. DiehlMarcin CieslikAndrea BajicNikoleta JureticShriya DeshmukhSriram VennetiTom W. MuirBenjamin A. GarciaNada JabadoPeter W. LewisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siddhant U. Jain Truman J. Do Peder J. Lund Andrew Q. Rashoff Katharine L. Diehl Marcin Cieslik Andrea Bajic Nikoleta Juretic Shriya Deshmukh Sriram Venneti Tom W. Muir Benjamin A. Garcia Nada Jabado Peter W. Lewis PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
description	PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to the K27M oncohistone.
format	article
author	Siddhant U. Jain Truman J. Do Peder J. Lund Andrew Q. Rashoff Katharine L. Diehl Marcin Cieslik Andrea Bajic Nikoleta Juretic Shriya Deshmukh Sriram Venneti Tom W. Muir Benjamin A. Garcia Nada Jabado Peter W. Lewis
author_facet	Siddhant U. Jain Truman J. Do Peder J. Lund Andrew Q. Rashoff Katharine L. Diehl Marcin Cieslik Andrea Bajic Nikoleta Juretic Shriya Deshmukh Sriram Venneti Tom W. Muir Benjamin A. Garcia Nada Jabado Peter W. Lewis
author_sort	Siddhant U. Jain
title	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
title_short	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
title_full	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
title_fullStr	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
title_full_unstemmed	PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
title_sort	pfa ependymoma-associated protein ezhip inhibits prc2 activity through a h3 k27m-like mechanism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a64b34bead04eeeabaa7ea08c232938
work_keys_str_mv	AT siddhantujain pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT trumanjdo pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT pederjlund pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT andrewqrashoff pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT katharineldiehl pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT marcincieslik pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT andreabajic pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT nikoletajuretic pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT shriyadeshmukh pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT sriramvenneti pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT tomwmuir pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT benjaminagarcia pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT nadajabado pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism AT peterwlewis pfaependymomaassociatedproteinezhipinhibitsprc2activitythroughah3k27mlikemechanism
_version_	1718382153257975808

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

Ejemplares similares