Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.

<h4>Background</h4>Despite current advances in liver transplant surgery, post-operative early allograft dysfunction still complicates the patient prognosis and graft survival. The transition from the donor has not been yet fully understood, and no study quantifies if and how the liver fu...

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Autores principales:	Vittorio Cherchi, Luigi Vetrugno, Giovanni Terrosu, Victor Zanini, Marco Ventin, Riccardo Pravisani, Francesco Tumminelli, Pier Paolo Brollo, Erica Boscolo, Roberto Peressutti, Dario Lorenzin, Tiziana Bove, Andrea Risaliti, Umberto Baccarani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a67fce5a59546548b79542625b993cd
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spelling	oai:doaj.org-article:7a67fce5a59546548b79542625b993cd2021-12-02T20:19:23ZAssociation between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.1932-620310.1371/journal.pone.0256786https://doaj.org/article/7a67fce5a59546548b79542625b993cd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256786https://doaj.org/toc/1932-6203<h4>Background</h4>Despite current advances in liver transplant surgery, post-operative early allograft dysfunction still complicates the patient prognosis and graft survival. The transition from the donor has not been yet fully understood, and no study quantifies if and how the liver function changes through its transfer to the recipient. The indocyanine green dye plasma disappearance rate (ICG-PDR) is a simple validated tool of liver function assessment. The variation rate between the donor and recipient ICG-PDR still needs to be investigated.<h4>Materials and methods</h4>Single-center retrospective study. ICG-PDR determinations were performed before graft retrieval (T1) and 24 hours after transplant (T2). The ICG-PDR relative variation rate between T1 and T2 was calculated to assess the graft function and suffering/recovering. Matched data were compared with the MEAF model of graft dysfunction.<h4>Objective</h4>To investigate whether the variation rate between the donor ICG-PDR value and the recipient ICG-PDR measurement on first postoperative day (POD1) can be associated with the MEAF score.<h4>Results</h4>36 ICG-PDR measurements between 18 donors and 18 graft recipients were performed. The mean donor ICG-PDR was 22.64 (SD 6.35), and the mean receiver's ICG-PDR on 1st POD was 17.68 (SD 6.60), with a mean MEAF value of 4.51 (SD 1.23). Pearson's test stressed a good, linear inverse correlation between the ICG-PDR relative variation and the MEAF values, correlation coefficient -0.580 (p = 0.012).<h4>Conclusion</h4>The direct correlation between the donor to recipient ICG-PDR variation rate and MEAF was found. Measurements at T1 and T2 showed an up- or downtrend of the graft performance that reflect the MEAF values.Vittorio CherchiLuigi VetrugnoGiovanni TerrosuVictor ZaniniMarco VentinRiccardo PravisaniFrancesco TumminelliPier Paolo BrolloErica BoscoloRoberto PeressuttiDario LorenzinTiziana BoveAndrea RisalitiUmberto BaccaraniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256786 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vittorio Cherchi Luigi Vetrugno Giovanni Terrosu Victor Zanini Marco Ventin Riccardo Pravisani Francesco Tumminelli Pier Paolo Brollo Erica Boscolo Roberto Peressutti Dario Lorenzin Tiziana Bove Andrea Risaliti Umberto Baccarani Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
description	<h4>Background</h4>Despite current advances in liver transplant surgery, post-operative early allograft dysfunction still complicates the patient prognosis and graft survival. The transition from the donor has not been yet fully understood, and no study quantifies if and how the liver function changes through its transfer to the recipient. The indocyanine green dye plasma disappearance rate (ICG-PDR) is a simple validated tool of liver function assessment. The variation rate between the donor and recipient ICG-PDR still needs to be investigated.<h4>Materials and methods</h4>Single-center retrospective study. ICG-PDR determinations were performed before graft retrieval (T1) and 24 hours after transplant (T2). The ICG-PDR relative variation rate between T1 and T2 was calculated to assess the graft function and suffering/recovering. Matched data were compared with the MEAF model of graft dysfunction.<h4>Objective</h4>To investigate whether the variation rate between the donor ICG-PDR value and the recipient ICG-PDR measurement on first postoperative day (POD1) can be associated with the MEAF score.<h4>Results</h4>36 ICG-PDR measurements between 18 donors and 18 graft recipients were performed. The mean donor ICG-PDR was 22.64 (SD 6.35), and the mean receiver's ICG-PDR on 1st POD was 17.68 (SD 6.60), with a mean MEAF value of 4.51 (SD 1.23). Pearson's test stressed a good, linear inverse correlation between the ICG-PDR relative variation and the MEAF values, correlation coefficient -0.580 (p = 0.012).<h4>Conclusion</h4>The direct correlation between the donor to recipient ICG-PDR variation rate and MEAF was found. Measurements at T1 and T2 showed an up- or downtrend of the graft performance that reflect the MEAF values.
format	article
author	Vittorio Cherchi Luigi Vetrugno Giovanni Terrosu Victor Zanini Marco Ventin Riccardo Pravisani Francesco Tumminelli Pier Paolo Brollo Erica Boscolo Roberto Peressutti Dario Lorenzin Tiziana Bove Andrea Risaliti Umberto Baccarani
author_facet	Vittorio Cherchi Luigi Vetrugno Giovanni Terrosu Victor Zanini Marco Ventin Riccardo Pravisani Francesco Tumminelli Pier Paolo Brollo Erica Boscolo Roberto Peressutti Dario Lorenzin Tiziana Bove Andrea Risaliti Umberto Baccarani
author_sort	Vittorio Cherchi
title	Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
title_short	Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
title_full	Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
title_fullStr	Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
title_full_unstemmed	Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.
title_sort	association between the donor to recipient icg-pdr variation rate and the functional recovery of the graft after orthotopic liver transplantation: a case series.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7a67fce5a59546548b79542625b993cd
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Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series.

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