The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.
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Nature Portfolio
2021
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oai:doaj.org-article:7a78efc95f94434186efe33c5a90c19a2021-12-02T16:36:00ZThe oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer10.1038/s41467-021-22101-72041-1723https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22101-7https://doaj.org/toc/2041-1723Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.Emily GoldenRabab RashwanEleanor A. WoodwardAgustin SgroEdina WangAnabel SorollaCharlene WaryahWan Jun TieElisabet CuyàsMagdalena RatajskaIwona KardaśPiotr KozlowskiElizabeth K. M. JohnstoneHeng B. SeeCiara DuffyJeremy ParryKim A. LagerborgPiotr CzapiewskiJavier A. MenendezAdam GorczyńskiBartosz WasagKevin D. G. PflegerChristina CurtisBum-Kyu LeeJonghwan KimJoseph CursonsNathan J. PavlosWojciech BiernatMohit JainAndrew J. WooAndrew RedfernPilar BlancafortNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
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Science Q Emily Golden Rabab Rashwan Eleanor A. Woodward Agustin Sgro Edina Wang Anabel Sorolla Charlene Waryah Wan Jun Tie Elisabet Cuyàs Magdalena Ratajska Iwona Kardaś Piotr Kozlowski Elizabeth K. M. Johnstone Heng B. See Ciara Duffy Jeremy Parry Kim A. Lagerborg Piotr Czapiewski Javier A. Menendez Adam Gorczyński Bartosz Wasag Kevin D. G. Pfleger Christina Curtis Bum-Kyu Lee Jonghwan Kim Joseph Cursons Nathan J. Pavlos Wojciech Biernat Mohit Jain Andrew J. Woo Andrew Redfern Pilar Blancafort The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| description |
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming. |
| format |
article |
| author |
Emily Golden Rabab Rashwan Eleanor A. Woodward Agustin Sgro Edina Wang Anabel Sorolla Charlene Waryah Wan Jun Tie Elisabet Cuyàs Magdalena Ratajska Iwona Kardaś Piotr Kozlowski Elizabeth K. M. Johnstone Heng B. See Ciara Duffy Jeremy Parry Kim A. Lagerborg Piotr Czapiewski Javier A. Menendez Adam Gorczyński Bartosz Wasag Kevin D. G. Pfleger Christina Curtis Bum-Kyu Lee Jonghwan Kim Joseph Cursons Nathan J. Pavlos Wojciech Biernat Mohit Jain Andrew J. Woo Andrew Redfern Pilar Blancafort |
| author_facet |
Emily Golden Rabab Rashwan Eleanor A. Woodward Agustin Sgro Edina Wang Anabel Sorolla Charlene Waryah Wan Jun Tie Elisabet Cuyàs Magdalena Ratajska Iwona Kardaś Piotr Kozlowski Elizabeth K. M. Johnstone Heng B. See Ciara Duffy Jeremy Parry Kim A. Lagerborg Piotr Czapiewski Javier A. Menendez Adam Gorczyński Bartosz Wasag Kevin D. G. Pfleger Christina Curtis Bum-Kyu Lee Jonghwan Kim Joseph Cursons Nathan J. Pavlos Wojciech Biernat Mohit Jain Andrew J. Woo Andrew Redfern Pilar Blancafort |
| author_sort |
Emily Golden |
| title |
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| title_short |
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| title_full |
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| title_fullStr |
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| title_full_unstemmed |
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| title_sort |
oncogene aamdc links pi3k-akt-mtor signaling with metabolic reprograming in estrogen receptor-positive breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a |
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