Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas

Ovarian cancer remains one of the most fatal pathologies among women around the world due to late diagnosis on the advanced stages of the tumor process. Serous ovarian carcinomas (SOC) often recur, which worsens the prognosis for patients’ recovery and survival. The identification of prognostic clin...

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Autor principal:	Varvara Hryhorenko
Formato:	article
Lenguaje:	EN
Publicado:	Scientific Route OÜ 2021
Materias:	lgsc vimentin e-cadherin emt cscs cd44 cd117 ovarian cancer figo stage ihc immunohistochemistry ihc markers Medicine R
Acceso en línea:	https://doaj.org/article/7a796e30effd4bceafba0e3490b76a9f
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spelling	oai:doaj.org-article:7a796e30effd4bceafba0e3490b76a9f2021-11-12T09:47:19ZPrognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas2585-66262585-663410.21303/2585-6634.2021.002130https://doaj.org/article/7a796e30effd4bceafba0e3490b76a9f2021-10-01T00:00:00Zhttp://journal.eu-jr.eu/ttism/article/view/2130https://doaj.org/toc/2585-6626https://doaj.org/toc/2585-6634Ovarian cancer remains one of the most fatal pathologies among women around the world due to late diagnosis on the advanced stages of the tumor process. Serous ovarian carcinomas (SOC) often recur, which worsens the prognosis for patients’ recovery and survival. The identification of prognostic clinical and morphological factors that predict the appearance of recurrence remains an urgent problem. The aim of the research was studying relationships between the phenomenon of epithelial-mesenchymal transformation (EMT) and the expression of surface cancer stem cells (CSCS) markers to identify recurrence predictors among women with low grade serous ovarian carcinomas (LGSC). The material were paraffin blocks and slides of 43 patients with LGSC I-IV FIGO stage. The study included 30 cancers without recurrence and 13 tumors with it within 24 months. The expression of E-cadherin, Vimentin, CD44 and CD117 was studied using immunohistochemical (IHC) method. Results. Development of recurrence is typical for women with stage III-IV (p=0,01), the expression of Vimentin at level 51–100 % (p=0,001) and E-cadherin at 10–50 % (p=0.04). CD44 was expressed in 51.16 % of tumors and level didn`t depend on age, recurrence, but depended on disease stage (p=0.001). Recurrent LGSCs are characterized by the expression of CD117> 10 % (p=0.0001), its direct correlation with the stage (p=0.0001) and the recurrence (p=0.0001). A direct relationship was found between the CD117 and Vimentin expression. Conclusions. Prognostic markers of recurrence should be considered stage III-IV, levels of Vimentin 51–100 %, E-cadherin 10-50 % and CD117> 10 %. A correlation between CD117 and Vimentin expression indicates the commonality of EMT and CSCS in progression and recur. CD44 has no independent prognostic role.Varvara HryhorenkoScientific Route OÜarticlelgscvimentine-cadherinemtcscscd44cd117ovarian cancerfigo stageihcimmunohistochemistryihc markersMedicineRENTechnology Transfer: Innovative Solutions in Medicine, Pp 16-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lgsc vimentin e-cadherin emt cscs cd44 cd117 ovarian cancer figo stage ihc immunohistochemistry ihc markers Medicine R
spellingShingle	lgsc vimentin e-cadherin emt cscs cd44 cd117 ovarian cancer figo stage ihc immunohistochemistry ihc markers Medicine R Varvara Hryhorenko Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
description	Ovarian cancer remains one of the most fatal pathologies among women around the world due to late diagnosis on the advanced stages of the tumor process. Serous ovarian carcinomas (SOC) often recur, which worsens the prognosis for patients’ recovery and survival. The identification of prognostic clinical and morphological factors that predict the appearance of recurrence remains an urgent problem. The aim of the research was studying relationships between the phenomenon of epithelial-mesenchymal transformation (EMT) and the expression of surface cancer stem cells (CSCS) markers to identify recurrence predictors among women with low grade serous ovarian carcinomas (LGSC). The material were paraffin blocks and slides of 43 patients with LGSC I-IV FIGO stage. The study included 30 cancers without recurrence and 13 tumors with it within 24 months. The expression of E-cadherin, Vimentin, CD44 and CD117 was studied using immunohistochemical (IHC) method. Results. Development of recurrence is typical for women with stage III-IV (p=0,01), the expression of Vimentin at level 51–100 % (p=0,001) and E-cadherin at 10–50 % (p=0.04). CD44 was expressed in 51.16 % of tumors and level didn`t depend on age, recurrence, but depended on disease stage (p=0.001). Recurrent LGSCs are characterized by the expression of CD117> 10 % (p=0.0001), its direct correlation with the stage (p=0.0001) and the recurrence (p=0.0001). A direct relationship was found between the CD117 and Vimentin expression. Conclusions. Prognostic markers of recurrence should be considered stage III-IV, levels of Vimentin 51–100 %, E-cadherin 10-50 % and CD117> 10 %. A correlation between CD117 and Vimentin expression indicates the commonality of EMT and CSCS in progression and recur. CD44 has no independent prognostic role.
format	article
author	Varvara Hryhorenko
author_facet	Varvara Hryhorenko
author_sort	Varvara Hryhorenko
title	Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
title_short	Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
title_full	Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
title_fullStr	Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
title_full_unstemmed	Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
title_sort	prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas
publisher	Scientific Route OÜ
publishDate	2021
url	https://doaj.org/article/7a796e30effd4bceafba0e3490b76a9f
work_keys_str_mv	AT varvarahryhorenko prognosisroleofepitelialmezenchimaltransformationmarkersandsurfacestemtumorcellsinthereccurenceofserouslowgradeovariancarcinomas
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Prognosis role of epitelial-mezenchimal transformation markers and surface stem tumor cells in the reccurence of serous low grade ovarian carcinomas

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