Functional Nanomedicines for Targeted Therapy of Bladder Cancer

Bladder cancer is one of most common malignant urinary tract tumor types with high incidence worldwide. In general, transurethral resection of non-muscle-invasive bladder cancer followed by intravesical instillation of chemotherapy is the standard treatment approach to minimize recurrence and delay...

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Autores principales:	Chao Tang, Heng Liu, Yanpeng Fan, Jiahao He, Fuqiu Li, Jin Wang, Yuchuan Hou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bladder cancer targeted therapy nanoparticle intravesical instillation chemotherapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7a7a2d4928e14df2831218a84f4f98b2
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spelling	oai:doaj.org-article:7a7a2d4928e14df2831218a84f4f98b22021-11-16T06:00:13ZFunctional Nanomedicines for Targeted Therapy of Bladder Cancer1663-981210.3389/fphar.2021.778973https://doaj.org/article/7a7a2d4928e14df2831218a84f4f98b22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.778973/fullhttps://doaj.org/toc/1663-9812Bladder cancer is one of most common malignant urinary tract tumor types with high incidence worldwide. In general, transurethral resection of non-muscle-invasive bladder cancer followed by intravesical instillation of chemotherapy is the standard treatment approach to minimize recurrence and delay progression of bladder cancer. However, conventional intravesical chemotherapy lacks selectivity for tumor tissues and the concentration of drug is reduced with the excretion of urine, leading to frequent administration and heavy local irritation symptoms. While nanomedicines can overcome all the above shortcomings and adhere to the surface of bladder tumors for a long time, and continuously and efficiently release drugs to bladder cancers. The rapid advances in targeted therapy have led to significant improvements in drug efficacy and precision of targeted drug delivery to eradicate tumor cells, with reduced side-effects. This review summarizes the different available nano-systems of targeted drug delivery to bladder cancer tissues. The challenges and prospects of targeted therapy for bladder cancer are additionally discussed.Chao TangHeng LiuYanpeng FanJiahao HeFuqiu LiJin WangYuchuan HouFrontiers Media S.A.articlebladder cancertargeted therapynanoparticleintravesical instillationchemotherapyTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer targeted therapy nanoparticle intravesical instillation chemotherapy Therapeutics. Pharmacology RM1-950
spellingShingle	bladder cancer targeted therapy nanoparticle intravesical instillation chemotherapy Therapeutics. Pharmacology RM1-950 Chao Tang Heng Liu Yanpeng Fan Jiahao He Fuqiu Li Jin Wang Yuchuan Hou Functional Nanomedicines for Targeted Therapy of Bladder Cancer
description	Bladder cancer is one of most common malignant urinary tract tumor types with high incidence worldwide. In general, transurethral resection of non-muscle-invasive bladder cancer followed by intravesical instillation of chemotherapy is the standard treatment approach to minimize recurrence and delay progression of bladder cancer. However, conventional intravesical chemotherapy lacks selectivity for tumor tissues and the concentration of drug is reduced with the excretion of urine, leading to frequent administration and heavy local irritation symptoms. While nanomedicines can overcome all the above shortcomings and adhere to the surface of bladder tumors for a long time, and continuously and efficiently release drugs to bladder cancers. The rapid advances in targeted therapy have led to significant improvements in drug efficacy and precision of targeted drug delivery to eradicate tumor cells, with reduced side-effects. This review summarizes the different available nano-systems of targeted drug delivery to bladder cancer tissues. The challenges and prospects of targeted therapy for bladder cancer are additionally discussed.
format	article
author	Chao Tang Heng Liu Yanpeng Fan Jiahao He Fuqiu Li Jin Wang Yuchuan Hou
author_facet	Chao Tang Heng Liu Yanpeng Fan Jiahao He Fuqiu Li Jin Wang Yuchuan Hou
author_sort	Chao Tang
title	Functional Nanomedicines for Targeted Therapy of Bladder Cancer
title_short	Functional Nanomedicines for Targeted Therapy of Bladder Cancer
title_full	Functional Nanomedicines for Targeted Therapy of Bladder Cancer
title_fullStr	Functional Nanomedicines for Targeted Therapy of Bladder Cancer
title_full_unstemmed	Functional Nanomedicines for Targeted Therapy of Bladder Cancer
title_sort	functional nanomedicines for targeted therapy of bladder cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7a7a2d4928e14df2831218a84f4f98b2
work_keys_str_mv	AT chaotang functionalnanomedicinesfortargetedtherapyofbladdercancer AT hengliu functionalnanomedicinesfortargetedtherapyofbladdercancer AT yanpengfan functionalnanomedicinesfortargetedtherapyofbladdercancer AT jiahaohe functionalnanomedicinesfortargetedtherapyofbladdercancer AT fuqiuli functionalnanomedicinesfortargetedtherapyofbladdercancer AT jinwang functionalnanomedicinesfortargetedtherapyofbladdercancer AT yuchuanhou functionalnanomedicinesfortargetedtherapyofbladdercancer
_version_	1718426674754748416

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

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