Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers

Abstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy...

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Autores principales:	Yang Liu, Paolo Maccarini, Gregory M. Palmer, Wiguins Etienne, Yulin Zhao, Chen-Ting Lee, Xiumei Ma, Brant A. Inman, Tuan Vo-Dinh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a7a54c93aa543e3b9bbc73ed1387d7a
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spelling	oai:doaj.org-article:7a7a54c93aa543e3b9bbc73ed1387d7a2021-12-02T16:06:47ZSynergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers10.1038/s41598-017-09116-12045-2322https://doaj.org/article/7a7a54c93aa543e3b9bbc73ed1387d7a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09116-1https://doaj.org/toc/2045-2322Abstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.Yang LiuPaolo MaccariniGregory M. PalmerWiguins EtienneYulin ZhaoChen-Ting LeeXiumei MaBrant A. InmanTuan Vo-DinhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
description	Abstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.
format	article
author	Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh
author_facet	Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh
author_sort	Yang Liu
title	Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
title_short	Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
title_full	Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
title_fullStr	Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
title_full_unstemmed	Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
title_sort	synergistic immuno photothermal nanotherapy (symphony) for the treatment of unresectable and metastatic cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7a7a54c93aa543e3b9bbc73ed1387d7a
work_keys_str_mv	AT yangliu synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT paolomaccarini synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT gregorympalmer synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT wiguinsetienne synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT yulinzhao synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT chentinglee synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT xiumeima synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT brantainman synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers AT tuanvodinh synergisticimmunophotothermalnanotherapysymphonyforthetreatmentofunresectableandmetastaticcancers
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Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers

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