Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.

Guardado en:

Detalles Bibliográficos
Autores principales:	Son C. Le, Zhiguang Jia, Jianhan Chen, Huanghe Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a7fbea43b5a481ab048b4ad58174d2f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a7fbea43b5a481ab048b4ad58174d2f
record_format	dspace
spelling	oai:doaj.org-article:7a7fbea43b5a481ab048b4ad58174d2f2021-12-02T17:01:27ZMolecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A10.1038/s41467-019-11784-82041-1723https://doaj.org/article/7a7fbea43b5a481ab048b4ad58174d2f2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11784-8https://doaj.org/toc/2041-1723The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.Son C. LeZhiguang JiaJianhan ChenHuanghe YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Son C. Le Zhiguang Jia Jianhan Chen Huanghe Yang Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
description	The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.
format	article
author	Son C. Le Zhiguang Jia Jianhan Chen Huanghe Yang
author_facet	Son C. Le Zhiguang Jia Jianhan Chen Huanghe Yang
author_sort	Son C. Le
title	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
title_short	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
title_full	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
title_fullStr	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
title_full_unstemmed	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
title_sort	molecular basis of pip2-dependent regulation of the ca2+-activated chloride channel tmem16a
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a7fbea43b5a481ab048b4ad58174d2f
work_keys_str_mv	AT soncle molecularbasisofpip2dependentregulationoftheca2activatedchloridechanneltmem16a AT zhiguangjia molecularbasisofpip2dependentregulationoftheca2activatedchloridechanneltmem16a AT jianhanchen molecularbasisofpip2dependentregulationoftheca2activatedchloridechanneltmem16a AT huangheyang molecularbasisofpip2dependentregulationoftheca2activatedchloridechanneltmem16a
_version_	1718382153513828352

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Ejemplares similares