Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.

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Detalles Bibliográficos
Autores principales: Son C. Le, Zhiguang Jia, Jianhan Chen, Huanghe Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/7a7fbea43b5a481ab048b4ad58174d2f
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