Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients

Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan Purpose: Ab interno trabeculectomy (AIT) with the Trabectome has been shown to reduce intraocular pressure (IOP) in eyes...

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Autores principales:	Tojo N, Abe S, Miyakoshi M, Hayashi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Pseudo exfoliation ab interno trabeculectomy contact lens sensor fluctuation intraocular pressure Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7a817d3e46124930ab0023f2c8041798
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spelling	oai:doaj.org-article:7a817d3e46124930ab0023f2c80417982021-12-02T07:44:55ZComparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients1177-5483https://doaj.org/article/7a817d3e46124930ab0023f2c80417982017-09-01T00:00:00Zhttps://www.dovepress.com/comparison-of-intraocular-pressure-fluctuations-before-and-after-ab-in-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan Purpose: Ab interno trabeculectomy (AIT) with the Trabectome has been shown to reduce intraocular pressure (IOP) in eyes with pseudoexfoliation (PEX) glaucoma. Here, we examined the change of IOP fluctuations before and after only AIT or AIT with cataract surgery in PEX patients using the contact lens sensor Triggerfish®.Methods: This was a prospective open-label study. Twenty-four consecutive patients with PEX glaucoma were included. Twelve patients underwent cataract surgery and AIT (triple-surgery group), and 12 patients underwent only AIT (single-surgery group). In each eye, IOP fluctuations over 24 h were measured with the contact lens sensor before and at 3 months after the surgery. We compared the change of IOP fluctuation before and after operation. We also evaluated the difference in IOP changes between the triple- and single-surgery groups.Results: At 3 months after the surgeries, the mean IOP was significantly reduced from 23.5±6.5 mmHg to 14.6±2.8 mmHg in the single-surgery group and from 22.5±3.0 mmHg to 11.5±2.9 mmHg in the triple-surgery group. The mean IOP reduction rate was significantly higher in the triple-surgery group compared to the single-surgery group (p=0.0358). In both groups, the mean range of IOP fluctuations was significantly decreased during nocturnal periods. The mean range of 24 h IOP fluctuations was decreased in the triple-surgery group (p=0.00425), not in the single-surgery group (p=0.970).Conclusion: Triple surgery could decrease IOP value and the IOP fluctuations to a greater extent than single surgery in PEX glaucoma patients. Keywords: pseudoexfoliation, ab interno trabeculectomy, contact lens sensor, fluctuation, intraocular pressureTojo NAbe SMiyakoshi MHayashi ADove Medical PressarticlePseudo exfoliationab interno trabeculectomycontact lens sensorfluctuationintraocular pressureOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1667-1675 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pseudo exfoliation ab interno trabeculectomy contact lens sensor fluctuation intraocular pressure Ophthalmology RE1-994
spellingShingle	Pseudo exfoliation ab interno trabeculectomy contact lens sensor fluctuation intraocular pressure Ophthalmology RE1-994 Tojo N Abe S Miyakoshi M Hayashi A Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
description	Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan Purpose: Ab interno trabeculectomy (AIT) with the Trabectome has been shown to reduce intraocular pressure (IOP) in eyes with pseudoexfoliation (PEX) glaucoma. Here, we examined the change of IOP fluctuations before and after only AIT or AIT with cataract surgery in PEX patients using the contact lens sensor Triggerfish®.Methods: This was a prospective open-label study. Twenty-four consecutive patients with PEX glaucoma were included. Twelve patients underwent cataract surgery and AIT (triple-surgery group), and 12 patients underwent only AIT (single-surgery group). In each eye, IOP fluctuations over 24 h were measured with the contact lens sensor before and at 3 months after the surgery. We compared the change of IOP fluctuation before and after operation. We also evaluated the difference in IOP changes between the triple- and single-surgery groups.Results: At 3 months after the surgeries, the mean IOP was significantly reduced from 23.5±6.5 mmHg to 14.6±2.8 mmHg in the single-surgery group and from 22.5±3.0 mmHg to 11.5±2.9 mmHg in the triple-surgery group. The mean IOP reduction rate was significantly higher in the triple-surgery group compared to the single-surgery group (p=0.0358). In both groups, the mean range of IOP fluctuations was significantly decreased during nocturnal periods. The mean range of 24 h IOP fluctuations was decreased in the triple-surgery group (p=0.00425), not in the single-surgery group (p=0.970).Conclusion: Triple surgery could decrease IOP value and the IOP fluctuations to a greater extent than single surgery in PEX glaucoma patients. Keywords: pseudoexfoliation, ab interno trabeculectomy, contact lens sensor, fluctuation, intraocular pressure
format	article
author	Tojo N Abe S Miyakoshi M Hayashi A
author_facet	Tojo N Abe S Miyakoshi M Hayashi A
author_sort	Tojo N
title	Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
title_short	Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
title_full	Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
title_fullStr	Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
title_full_unstemmed	Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
title_sort	comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7a817d3e46124930ab0023f2c8041798
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Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients

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