Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure

Rana H Mosli,1 Hala H Mosli2 1Clinical Nutrition Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Ar...

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Autores principales:	Mosli RH, Mosli HH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Obesity morbid obesity albumin hypoalbuminemia inflammation diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/7a826358c6e54575b0d3d4ab9f13d834
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spelling	oai:doaj.org-article:7a826358c6e54575b0d3d4ab9f13d8342021-12-02T08:19:46ZObesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure1178-7007https://doaj.org/article/7a826358c6e54575b0d3d4ab9f13d8342017-11-01T00:00:00Zhttps://www.dovepress.com/obesity-and-morbid-obesity-associated-with-higher-odds-of-hypoalbumine-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Rana H Mosli,1 Hala H Mosli2 1Clinical Nutrition Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia Background and objective: Studies are needed in order to inform recommendations for interpreting albumin levels among obese individuals without known medical conditions associated with hypoalbuminemia. The objective of this study was to examine the association of obese and morbidly obese status with hypoalbuminemia, while adjusting for age, sex, diabetes, prediabetes, diabetic nephropathy, and nephrotic syndrome.Patients and methods: Retrospective data collection from adult patients presenting to the outpatient Endocrinology and Metabolism Clinic was performed between January 2015 and December 2015. An initial sample of 180 patients was selected. After excluding patients who were younger than 18 years, who had known cases of liver disease or renal failure, or who had missing data, a final sample of 122 subjects was identified. Serum albumin and objectively measured weight and height data were retrieved from hospital records. A board-certified endocrinologist reviewed patient records to identify the presence of renal and diabetic conditions. Descriptive statistics were used to examine sample characteristics. Multiple logistic regression analysis was used to examine the association of obesity and morbid obesity with hypoalbuminemia (serum albumin < 34 g/L) while adjusting for age, sex, diabetes, prediabetes, diabetic nephropathy, and nephrotic syndrome.Results: Approximately 43% of the sample were categorized as obese and 13% were categorized as morbidly obese. The mean serum albumin level was 38.00 g/L (standard deviation [SD] = 4.26) among subjects who were neither overweight nor obese, 38.35 g/L (SD = 0.48) among overweight subjects, 34.57 g/L (SD = 4.71) among obese subjects, and 33.81 g/L (SD = 3.71) among morbidly obese subjects. Adjusting for age, sex, diabetes, prediabetes, nephrotic syndrome, and diabetic nephropathy, obese subjects had significantly higher odds of hypoalbuminemia (odds ratio [OR]: 4.10, 95% confidence interval [CI]: 1.50–11.27, P-value = 0.006), as did morbidly obese subjects (OR: 6.94, 95% CI: 1.91–25.23, P-value = 0.003).Conclusion: The findings suggest that obesity and morbid obesity can be considered as independent predictors of hypoalbuminemia. The findings can be used to inform future studies aiming to better understand the association of obesity and morbid obesity with hypoalbuminemia and to help inform guidelines for clinicians on how to correctly interpret and utilize serum albumin data for obese individuals. Keywords: obesity, morbid obesity, albumin, hypoalbuminemia, inflammation, diabetes mellitus Mosli RHMosli HHDove Medical PressarticleObesitymorbid obesityalbuminhypoalbuminemiainflammationdiabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 467-472 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity morbid obesity albumin hypoalbuminemia inflammation diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	Obesity morbid obesity albumin hypoalbuminemia inflammation diabetes mellitus Specialties of internal medicine RC581-951 Mosli RH Mosli HH Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
description	Rana H Mosli,1 Hala H Mosli2 1Clinical Nutrition Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia Background and objective: Studies are needed in order to inform recommendations for interpreting albumin levels among obese individuals without known medical conditions associated with hypoalbuminemia. The objective of this study was to examine the association of obese and morbidly obese status with hypoalbuminemia, while adjusting for age, sex, diabetes, prediabetes, diabetic nephropathy, and nephrotic syndrome.Patients and methods: Retrospective data collection from adult patients presenting to the outpatient Endocrinology and Metabolism Clinic was performed between January 2015 and December 2015. An initial sample of 180 patients was selected. After excluding patients who were younger than 18 years, who had known cases of liver disease or renal failure, or who had missing data, a final sample of 122 subjects was identified. Serum albumin and objectively measured weight and height data were retrieved from hospital records. A board-certified endocrinologist reviewed patient records to identify the presence of renal and diabetic conditions. Descriptive statistics were used to examine sample characteristics. Multiple logistic regression analysis was used to examine the association of obesity and morbid obesity with hypoalbuminemia (serum albumin < 34 g/L) while adjusting for age, sex, diabetes, prediabetes, diabetic nephropathy, and nephrotic syndrome.Results: Approximately 43% of the sample were categorized as obese and 13% were categorized as morbidly obese. The mean serum albumin level was 38.00 g/L (standard deviation [SD] = 4.26) among subjects who were neither overweight nor obese, 38.35 g/L (SD = 0.48) among overweight subjects, 34.57 g/L (SD = 4.71) among obese subjects, and 33.81 g/L (SD = 3.71) among morbidly obese subjects. Adjusting for age, sex, diabetes, prediabetes, nephrotic syndrome, and diabetic nephropathy, obese subjects had significantly higher odds of hypoalbuminemia (odds ratio [OR]: 4.10, 95% confidence interval [CI]: 1.50–11.27, P-value = 0.006), as did morbidly obese subjects (OR: 6.94, 95% CI: 1.91–25.23, P-value = 0.003).Conclusion: The findings suggest that obesity and morbid obesity can be considered as independent predictors of hypoalbuminemia. The findings can be used to inform future studies aiming to better understand the association of obesity and morbid obesity with hypoalbuminemia and to help inform guidelines for clinicians on how to correctly interpret and utilize serum albumin data for obese individuals. Keywords: obesity, morbid obesity, albumin, hypoalbuminemia, inflammation, diabetes mellitus
format	article
author	Mosli RH Mosli HH
author_facet	Mosli RH Mosli HH
author_sort	Mosli RH
title	Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
title_short	Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
title_full	Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
title_fullStr	Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
title_full_unstemmed	Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
title_sort	obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7a826358c6e54575b0d3d4ab9f13d834
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Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure

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