Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs

Canid herpesvirus 1 (CaHV-1) is a member of the canine infectious respiratory disease complex (CIRDC). The outcome of CaHV-1 infection can be occasionally fatal. So far, no information on CaHV-1 circulation in Thailand has been reported resulting in a lack of preventive strategies. In this study, na...

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Autores principales:	Piewbang Chutchai, Rungsipipat Anudep, Poovorawan Yong, Techangamsuwan Somporn
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	canid herpesvirus 1 cirdc pathology respiratory distress thailand Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/7a83af59218745008c9ea814b2ca4273
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spelling	oai:doaj.org-article:7a83af59218745008c9ea814b2ca42732021-11-17T21:27:51ZViral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs1820-744810.1515/acve-2017-0002https://doaj.org/article/7a83af59218745008c9ea814b2ca42732017-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0002https://doaj.org/toc/1820-7448Canid herpesvirus 1 (CaHV-1) is a member of the canine infectious respiratory disease complex (CIRDC). The outcome of CaHV-1 infection can be occasionally fatal. So far, no information on CaHV-1 circulation in Thailand has been reported resulting in a lack of preventive strategies. In this study, nasal (NS) and oropharyngeal (OS) swabs were collected from 100 live dogs with respiratory distress. Among them, 23 pleural effusions were aspirated. A panel of CIRDC-associated viruses was screened by (RT)-PCR, including CaHV-1, CIV, CPIV, CDV, CRCoV and CAdV-2, for all collected samples. The CaHV-1 was detected in 32 dogs. Additionally, CaHV-1 was consistently detected in six pleural effusions. Most CaHV-1 infected dogs were over 5 years of age (43.8%) and expressed a mild nasal discharge. Pathological results of four three-month-old puppies, naturally moribund from respiratory disease, revealed a severe multifocal necrotic-hemorrhagic disease in several organs without pathognomonic inclusion bodies. They were only found to be CaHV-1 positive by PCR. Phylogenetic analysis demonstrated concordant results of CaHV-1 circulation in Thailand. Although mostly found as a co-infection with other CIRDC viruses (68.8%) it also occurred alone. Therefore, rapid ante-mortem diagnosis might facilitate the investigation of unclassical CaHV-1 infection, which is fatal in neonates and causes illness in annually core-vaccinated adults.Piewbang ChutchaiRungsipipat AnudepPoovorawan YongTechangamsuwan SompornSciendoarticlecanid herpesvirus 1cirdcpathologyrespiratory distressthailandVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 1, Pp 11-24 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	canid herpesvirus 1 cirdc pathology respiratory distress thailand Veterinary medicine SF600-1100
spellingShingle	canid herpesvirus 1 cirdc pathology respiratory distress thailand Veterinary medicine SF600-1100 Piewbang Chutchai Rungsipipat Anudep Poovorawan Yong Techangamsuwan Somporn Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
description	Canid herpesvirus 1 (CaHV-1) is a member of the canine infectious respiratory disease complex (CIRDC). The outcome of CaHV-1 infection can be occasionally fatal. So far, no information on CaHV-1 circulation in Thailand has been reported resulting in a lack of preventive strategies. In this study, nasal (NS) and oropharyngeal (OS) swabs were collected from 100 live dogs with respiratory distress. Among them, 23 pleural effusions were aspirated. A panel of CIRDC-associated viruses was screened by (RT)-PCR, including CaHV-1, CIV, CPIV, CDV, CRCoV and CAdV-2, for all collected samples. The CaHV-1 was detected in 32 dogs. Additionally, CaHV-1 was consistently detected in six pleural effusions. Most CaHV-1 infected dogs were over 5 years of age (43.8%) and expressed a mild nasal discharge. Pathological results of four three-month-old puppies, naturally moribund from respiratory disease, revealed a severe multifocal necrotic-hemorrhagic disease in several organs without pathognomonic inclusion bodies. They were only found to be CaHV-1 positive by PCR. Phylogenetic analysis demonstrated concordant results of CaHV-1 circulation in Thailand. Although mostly found as a co-infection with other CIRDC viruses (68.8%) it also occurred alone. Therefore, rapid ante-mortem diagnosis might facilitate the investigation of unclassical CaHV-1 infection, which is fatal in neonates and causes illness in annually core-vaccinated adults.
format	article
author	Piewbang Chutchai Rungsipipat Anudep Poovorawan Yong Techangamsuwan Somporn
author_facet	Piewbang Chutchai Rungsipipat Anudep Poovorawan Yong Techangamsuwan Somporn
author_sort	Piewbang Chutchai
title	Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
title_short	Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
title_full	Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
title_fullStr	Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
title_full_unstemmed	Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
title_sort	viral molecular and pathological investigations of canid herpesvirus 1 infection associated respiratory disease and acute death in dogs
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/7a83af59218745008c9ea814b2ca4273
work_keys_str_mv	AT piewbangchutchai viralmolecularandpathologicalinvestigationsofcanidherpesvirus1infectionassociatedrespiratorydiseaseandacutedeathindogs AT rungsipipatanudep viralmolecularandpathologicalinvestigationsofcanidherpesvirus1infectionassociatedrespiratorydiseaseandacutedeathindogs AT poovorawanyong viralmolecularandpathologicalinvestigationsofcanidherpesvirus1infectionassociatedrespiratorydiseaseandacutedeathindogs AT techangamsuwansomporn viralmolecularandpathologicalinvestigationsofcanidherpesvirus1infectionassociatedrespiratorydiseaseandacutedeathindogs
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Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs

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