Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes

Abstract The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity...

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Autores principales:	Andrew J. Hall, Amy G. Robertson, Leila R. Hill, Louis M. Rendina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a84110a601e4dbd8122cc98fa621c4d
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spelling	oai:doaj.org-article:7a84110a601e4dbd8122cc98fa621c4d2021-12-02T14:12:08ZSynthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes10.1038/s41598-020-79893-92045-2322https://doaj.org/article/7a84110a601e4dbd8122cc98fa621c4d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79893-9https://doaj.org/toc/2045-2322Abstract The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.Andrew J. HallAmy G. RobertsonLeila R. HillLouis M. RendinaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew J. Hall Amy G. Robertson Leila R. Hill Louis M. Rendina Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
description	Abstract The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.
format	article
author	Andrew J. Hall Amy G. Robertson Leila R. Hill Louis M. Rendina
author_facet	Andrew J. Hall Amy G. Robertson Leila R. Hill Louis M. Rendina
author_sort	Andrew J. Hall
title	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_short	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_full	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_fullStr	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_full_unstemmed	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
title_sort	synthesis and tumour cell uptake studies of gadolinium(iii)–phosphonium complexes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a84110a601e4dbd8122cc98fa621c4d
work_keys_str_mv	AT andrewjhall synthesisandtumourcelluptakestudiesofgadoliniumiiiphosphoniumcomplexes AT amygrobertson synthesisandtumourcelluptakestudiesofgadoliniumiiiphosphoniumcomplexes AT leilarhill synthesisandtumourcelluptakestudiesofgadoliniumiiiphosphoniumcomplexes AT louismrendina synthesisandtumourcelluptakestudiesofgadoliniumiiiphosphoniumcomplexes
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Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes

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