YAP and TAZ protect against white adipocyte cell death during obesity

The expansion of the white adipose tissue during obesity is accompanied by increased cellular stress, but factors that protect adipocytes from cell death are not well known. Here the authors report that the transcriptional co-activators YAP and TAZ are activated in adipocytes during obesity, which i...

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Autores principales:	Lei Wang, ShengPeng Wang, Yue Shi, Rui Li, Stefan Günther, Yu Ting Ong, Michael Potente, Zuyi Yuan, Enqi Liu, Stefan Offermanns
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a8432b5796c4c8c88ffb842b61592ee
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spelling	oai:doaj.org-article:7a8432b5796c4c8c88ffb842b61592ee2021-12-02T17:32:13ZYAP and TAZ protect against white adipocyte cell death during obesity10.1038/s41467-020-19229-32041-1723https://doaj.org/article/7a8432b5796c4c8c88ffb842b61592ee2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19229-3https://doaj.org/toc/2041-1723The expansion of the white adipose tissue during obesity is accompanied by increased cellular stress, but factors that protect adipocytes from cell death are not well known. Here the authors report that the transcriptional co-activators YAP and TAZ are activated in adipocytes during obesity, which increases adipocyte survival through the proapoptotic factor BIM.Lei WangShengPeng WangYue ShiRui LiStefan GüntherYu Ting OngMichael PotenteZuyi YuanEnqi LiuStefan OffermannsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Wang ShengPeng Wang Yue Shi Rui Li Stefan Günther Yu Ting Ong Michael Potente Zuyi Yuan Enqi Liu Stefan Offermanns YAP and TAZ protect against white adipocyte cell death during obesity
description	The expansion of the white adipose tissue during obesity is accompanied by increased cellular stress, but factors that protect adipocytes from cell death are not well known. Here the authors report that the transcriptional co-activators YAP and TAZ are activated in adipocytes during obesity, which increases adipocyte survival through the proapoptotic factor BIM.
format	article
author	Lei Wang ShengPeng Wang Yue Shi Rui Li Stefan Günther Yu Ting Ong Michael Potente Zuyi Yuan Enqi Liu Stefan Offermanns
author_facet	Lei Wang ShengPeng Wang Yue Shi Rui Li Stefan Günther Yu Ting Ong Michael Potente Zuyi Yuan Enqi Liu Stefan Offermanns
author_sort	Lei Wang
title	YAP and TAZ protect against white adipocyte cell death during obesity
title_short	YAP and TAZ protect against white adipocyte cell death during obesity
title_full	YAP and TAZ protect against white adipocyte cell death during obesity
title_fullStr	YAP and TAZ protect against white adipocyte cell death during obesity
title_full_unstemmed	YAP and TAZ protect against white adipocyte cell death during obesity
title_sort	yap and taz protect against white adipocyte cell death during obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7a8432b5796c4c8c88ffb842b61592ee
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YAP and TAZ protect against white adipocyte cell death during obesity

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