Development and application of a high-content virion display human GPCR array

G protein-coupled receptors (GPCRs) are important targets for drug discovery. Here, the authors develop a Virion Display array of 315 functional non-odorant GPCRs, providing a platform for high-throughput, unbiased screening for small molecule drugs, affinity reagents, and microbial interactions.

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Autores principales:	Guan-Da Syu, Shih-Chin Wang, Guangzhong Ma, Shuang Liu, Donna Pearce, Atish Prakash, Brandon Henson, Lien-Chun Weng, Devlina Ghosh, Pedro Ramos, Daniel Eichinger, Ignacio Pino, Xinzhong Dong, Jie Xiao, Shaopeng Wang, Nongjian Tao, Kwang Sik Kim, Prashant J. Desai, Heng Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a853ae4a1c340a6a212e52e60b8d905
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spelling	oai:doaj.org-article:7a853ae4a1c340a6a212e52e60b8d9052021-12-02T17:01:29ZDevelopment and application of a high-content virion display human GPCR array10.1038/s41467-019-09938-92041-1723https://doaj.org/article/7a853ae4a1c340a6a212e52e60b8d9052019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09938-9https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs) are important targets for drug discovery. Here, the authors develop a Virion Display array of 315 functional non-odorant GPCRs, providing a platform for high-throughput, unbiased screening for small molecule drugs, affinity reagents, and microbial interactions.Guan-Da SyuShih-Chin WangGuangzhong MaShuang LiuDonna PearceAtish PrakashBrandon HensonLien-Chun WengDevlina GhoshPedro RamosDaniel EichingerIgnacio PinoXinzhong DongJie XiaoShaopeng WangNongjian TaoKwang Sik KimPrashant J. DesaiHeng ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guan-Da Syu Shih-Chin Wang Guangzhong Ma Shuang Liu Donna Pearce Atish Prakash Brandon Henson Lien-Chun Weng Devlina Ghosh Pedro Ramos Daniel Eichinger Ignacio Pino Xinzhong Dong Jie Xiao Shaopeng Wang Nongjian Tao Kwang Sik Kim Prashant J. Desai Heng Zhu Development and application of a high-content virion display human GPCR array
description	G protein-coupled receptors (GPCRs) are important targets for drug discovery. Here, the authors develop a Virion Display array of 315 functional non-odorant GPCRs, providing a platform for high-throughput, unbiased screening for small molecule drugs, affinity reagents, and microbial interactions.
format	article
author	Guan-Da Syu Shih-Chin Wang Guangzhong Ma Shuang Liu Donna Pearce Atish Prakash Brandon Henson Lien-Chun Weng Devlina Ghosh Pedro Ramos Daniel Eichinger Ignacio Pino Xinzhong Dong Jie Xiao Shaopeng Wang Nongjian Tao Kwang Sik Kim Prashant J. Desai Heng Zhu
author_facet	Guan-Da Syu Shih-Chin Wang Guangzhong Ma Shuang Liu Donna Pearce Atish Prakash Brandon Henson Lien-Chun Weng Devlina Ghosh Pedro Ramos Daniel Eichinger Ignacio Pino Xinzhong Dong Jie Xiao Shaopeng Wang Nongjian Tao Kwang Sik Kim Prashant J. Desai Heng Zhu
author_sort	Guan-Da Syu
title	Development and application of a high-content virion display human GPCR array
title_short	Development and application of a high-content virion display human GPCR array
title_full	Development and application of a high-content virion display human GPCR array
title_fullStr	Development and application of a high-content virion display human GPCR array
title_full_unstemmed	Development and application of a high-content virion display human GPCR array
title_sort	development and application of a high-content virion display human gpcr array
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a853ae4a1c340a6a212e52e60b8d905
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Development and application of a high-content virion display human GPCR array

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