A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional hom...

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Auteurs principaux:	Deepak Koirala, Yaming Shao, Yelena Koldobskaya, James R. Fuller, Andrew M. Watkins, Sandip A. Shelke, Evgeny V. Pilipenko, Rhiju Das, Phoebe A. Rice, Joseph A. Piccirilli
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7a89e6027bf4428f95ad4027eb511ff7
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spelling	oai:doaj.org-article:7a89e6027bf4428f95ad4027eb511ff72021-12-02T17:01:47ZA conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites10.1038/s41467-019-11585-z2041-1723https://doaj.org/article/7a89e6027bf4428f95ad4027eb511ff72019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11585-zhttps://doaj.org/toc/2041-1723Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional homology among different types of picornaviral IRESs is structure-based.Deepak KoiralaYaming ShaoYelena KoldobskayaJames R. FullerAndrew M. WatkinsSandip A. ShelkeEvgeny V. PilipenkoRhiju DasPhoebe A. RiceJoseph A. PiccirilliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepak Koirala Yaming Shao Yelena Koldobskaya James R. Fuller Andrew M. Watkins Sandip A. Shelke Evgeny V. Pilipenko Rhiju Das Phoebe A. Rice Joseph A. Piccirilli A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
description	Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional homology among different types of picornaviral IRESs is structure-based.
format	article
author	Deepak Koirala Yaming Shao Yelena Koldobskaya James R. Fuller Andrew M. Watkins Sandip A. Shelke Evgeny V. Pilipenko Rhiju Das Phoebe A. Rice Joseph A. Piccirilli
author_facet	Deepak Koirala Yaming Shao Yelena Koldobskaya James R. Fuller Andrew M. Watkins Sandip A. Shelke Evgeny V. Pilipenko Rhiju Das Phoebe A. Rice Joseph A. Piccirilli
author_sort	Deepak Koirala
title	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
title_short	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
title_full	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
title_fullStr	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
title_full_unstemmed	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
title_sort	conserved rna structural motif for organizing topology within picornaviral internal ribosome entry sites
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a89e6027bf4428f95ad4027eb511ff7
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A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

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