Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast

Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis and secretion of bioactive penicillin.

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Autores principales:	Ali R. Awan, Benjamin A. Blount, David J. Bell, William M. Shaw, Jack C.H. Ho, Robert M. McKiernan, Tom Ellis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a8a3b1bad90498c8b14527c0c764e0e
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spelling	oai:doaj.org-article:7a8a3b1bad90498c8b14527c0c764e0e2021-12-02T14:40:47ZBiosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast10.1038/ncomms152022041-1723https://doaj.org/article/7a8a3b1bad90498c8b14527c0c764e0e2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15202https://doaj.org/toc/2041-1723Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis and secretion of bioactive penicillin.Ali R. AwanBenjamin A. BlountDavid J. BellWilliam M. ShawJack C.H. HoRobert M. McKiernanTom EllisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ali R. Awan Benjamin A. Blount David J. Bell William M. Shaw Jack C.H. Ho Robert M. McKiernan Tom Ellis Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
description	Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis and secretion of bioactive penicillin.
format	article
author	Ali R. Awan Benjamin A. Blount David J. Bell William M. Shaw Jack C.H. Ho Robert M. McKiernan Tom Ellis
author_facet	Ali R. Awan Benjamin A. Blount David J. Bell William M. Shaw Jack C.H. Ho Robert M. McKiernan Tom Ellis
author_sort	Ali R. Awan
title	Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
title_short	Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
title_full	Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
title_fullStr	Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
title_full_unstemmed	Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
title_sort	biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7a8a3b1bad90498c8b14527c0c764e0e
work_keys_str_mv	AT alirawan biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT benjaminablount biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT davidjbell biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT williammshaw biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT jackchho biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT robertmmckiernan biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast AT tomellis biosynthesisoftheantibioticnonribosomalpeptidepenicillininbakersyeast
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Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast

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