Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes

Minoru Kawaguchi1,2, Jun Ohno2,3, Akihito Irie4, Tadao Fukushima2,5, Jun Yamazaki2,6, Naotoshi Nakashima2,71Department of Dental Engineering, Biomaterials Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 2Japan Science and Technology Agency (JST), Core Research of Evolutional Science and...

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Autores principales:	Kawaguchi M, Ohno J, Irie A, Fukushima T, Yamazaki J, Nakashima N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7a8eaac320d3481798d663dab2bf8607
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spelling	oai:doaj.org-article:7a8eaac320d3481798d663dab2bf86072021-12-02T02:04:09ZDispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes1176-91141178-2013https://doaj.org/article/7a8eaac320d3481798d663dab2bf86072011-04-01T00:00:00Zhttp://www.dovepress.com/dispersion-stability-and-exothermic-properties-of-dna-functionalized-s-a7045https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Minoru Kawaguchi1,2, Jun Ohno2,3, Akihito Irie4, Tadao Fukushima2,5, Jun Yamazaki2,6, Naotoshi Nakashima2,71Department of Dental Engineering, Biomaterials Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 2Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan; 3Department of Morphological Biology, Pathology Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 4Department of Oral Rehabilitation, Section of Oral Implantology, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 5Department of Dental Engineering, Bioengineering Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 6Department of Physiological Science and Molecular Biology, Section of cellular and Molecular Regulation, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 7Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Nishi-ku, Fukuoka, JapanAbstract: Carbon nanotubes act as a photon antenna that serves as an effective &ldquo;molecular heater&rdquo; around the near-infrared (NIR) region. This exothermic generation can be used as a possible heating source for hyperthermia therapy. The current study reports the dispersible and exothermic properties with NIR irradiation for single-walled carbon nanotubes (SWNTs) treated with a strong acid (acid-treated SWNTs), and the SWNTs further functionalized with double-stranded DNA (DNA-functionalized SWNTs: DNA-SWNTs). DNA-SWNTs significantly improved the dispersibility of SWNTs when compared with the acid-treated SWNTs. The binding ratio of the acid-treated SWNT and DNA was calculated to be 3.1 (DNA/SWNTs) from the phosphorous content in the DNA-SWNT. This interaction of the SWNTs and DNA would contribute to the stable dispersion of the DNA-SWNTs in a culture medium. With NIR irradiation by a halogen lamp light source, the acid-treated SWNTs and the DNA-SWNTs showed strong heat evolution in vitro (in a culture medium) and in vivo (in the subcutaneous tissue of a mouse) condition without any invasive effect on the non-SWNT area. The results of this study suggested that the functionalization with DNA was an efficient approach to improve the dispersibility of SWNTs in body fluids, and the DNA-SWNT would be a promising source for photo-induced exothermic generation.Keywords: DNA functionalization, near-infrared irradiation Kawaguchi MOhno JIrie AFukushima TYamazaki JNakashima NDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 729-736 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kawaguchi M Ohno J Irie A Fukushima T Yamazaki J Nakashima N Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
description	Minoru Kawaguchi1,2, Jun Ohno2,3, Akihito Irie4, Tadao Fukushima2,5, Jun Yamazaki2,6, Naotoshi Nakashima2,71Department of Dental Engineering, Biomaterials Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 2Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan; 3Department of Morphological Biology, Pathology Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 4Department of Oral Rehabilitation, Section of Oral Implantology, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 5Department of Dental Engineering, Bioengineering Section, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 6Department of Physiological Science and Molecular Biology, Section of cellular and Molecular Regulation, Fukuoka Dental College, Sawara-ku, Fukuoka, Japan; 7Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Nishi-ku, Fukuoka, JapanAbstract: Carbon nanotubes act as a photon antenna that serves as an effective &ldquo;molecular heater&rdquo; around the near-infrared (NIR) region. This exothermic generation can be used as a possible heating source for hyperthermia therapy. The current study reports the dispersible and exothermic properties with NIR irradiation for single-walled carbon nanotubes (SWNTs) treated with a strong acid (acid-treated SWNTs), and the SWNTs further functionalized with double-stranded DNA (DNA-functionalized SWNTs: DNA-SWNTs). DNA-SWNTs significantly improved the dispersibility of SWNTs when compared with the acid-treated SWNTs. The binding ratio of the acid-treated SWNT and DNA was calculated to be 3.1 (DNA/SWNTs) from the phosphorous content in the DNA-SWNT. This interaction of the SWNTs and DNA would contribute to the stable dispersion of the DNA-SWNTs in a culture medium. With NIR irradiation by a halogen lamp light source, the acid-treated SWNTs and the DNA-SWNTs showed strong heat evolution in vitro (in a culture medium) and in vivo (in the subcutaneous tissue of a mouse) condition without any invasive effect on the non-SWNT area. The results of this study suggested that the functionalization with DNA was an efficient approach to improve the dispersibility of SWNTs in body fluids, and the DNA-SWNT would be a promising source for photo-induced exothermic generation.Keywords: DNA functionalization, near-infrared irradiation
format	article
author	Kawaguchi M Ohno J Irie A Fukushima T Yamazaki J Nakashima N
author_facet	Kawaguchi M Ohno J Irie A Fukushima T Yamazaki J Nakashima N
author_sort	Kawaguchi M
title	Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
title_short	Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
title_full	Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
title_fullStr	Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
title_full_unstemmed	Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes
title_sort	dispersion stability and exothermic properties of dna-functionalized single-walled carbon nanotubes
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/7a8eaac320d3481798d663dab2bf8607
work_keys_str_mv	AT kawaguchim dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes AT ohnoj dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes AT iriea dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes AT fukushimat dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes AT yamazakij dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes AT nakashiman dispersionstabilityandexothermicpropertiesofdnafunctionalizedsinglewalledcarbonnanotubes
_version_	1718402713597771776

Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes

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