The Role of Exosomes and Their Applications in Cancer

Exosomes are very small extracellular vesicles secreted by multiple cell types and are extensively distributed in various biological fluids. Recent research indicated that exosomes can participate in regulating the tumor microenvironment and impacting tumor proliferation and progression. Due to the...

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Autores principales:	Yuju Zhou, Ying Zhang, Huan Gong, Siqi Luo, Yan Cui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	exosomes tumor microenvironment cancers applications Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7a90bea6bb9f4e9da0fe363f93ab957e
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spelling	oai:doaj.org-article:7a90bea6bb9f4e9da0fe363f93ab957e2021-11-25T17:54:18ZThe Role of Exosomes and Their Applications in Cancer10.3390/ijms2222122041422-00671661-6596https://doaj.org/article/7a90bea6bb9f4e9da0fe363f93ab957e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12204https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Exosomes are very small extracellular vesicles secreted by multiple cell types and are extensively distributed in various biological fluids. Recent research indicated that exosomes can participate in regulating the tumor microenvironment and impacting tumor proliferation and progression. Due to the extensive enrollment in cancer development, exosomes have become a focus of the search for a new therapeutic method for cancer. Exosomes can be utilized for the therapeutic delivery of small molecules, proteins and RNAs to target cancer cells with a high efficiency. Exosome-carried proteins, lipids and nucleic acids are being tested as promising biomarkers for cancer diagnosis and prognosis, even as potential treatment targets for cancer. Moreover, different sources of exosomes exhibit multiple performances in cancer applications. In this review, we elaborate on the specific mechanism by which exosomes affect the communication between tumors and the microenvironment and state the therapeutic and diagnostic applications of exosomes in cancers.Yuju ZhouYing ZhangHuan GongSiqi LuoYan CuiMDPI AGarticleexosomestumor microenvironmentcancersapplicationsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12204, p 12204 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes tumor microenvironment cancers applications Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	exosomes tumor microenvironment cancers applications Biology (General) QH301-705.5 Chemistry QD1-999 Yuju Zhou Ying Zhang Huan Gong Siqi Luo Yan Cui The Role of Exosomes and Their Applications in Cancer
description	Exosomes are very small extracellular vesicles secreted by multiple cell types and are extensively distributed in various biological fluids. Recent research indicated that exosomes can participate in regulating the tumor microenvironment and impacting tumor proliferation and progression. Due to the extensive enrollment in cancer development, exosomes have become a focus of the search for a new therapeutic method for cancer. Exosomes can be utilized for the therapeutic delivery of small molecules, proteins and RNAs to target cancer cells with a high efficiency. Exosome-carried proteins, lipids and nucleic acids are being tested as promising biomarkers for cancer diagnosis and prognosis, even as potential treatment targets for cancer. Moreover, different sources of exosomes exhibit multiple performances in cancer applications. In this review, we elaborate on the specific mechanism by which exosomes affect the communication between tumors and the microenvironment and state the therapeutic and diagnostic applications of exosomes in cancers.
format	article
author	Yuju Zhou Ying Zhang Huan Gong Siqi Luo Yan Cui
author_facet	Yuju Zhou Ying Zhang Huan Gong Siqi Luo Yan Cui
author_sort	Yuju Zhou
title	The Role of Exosomes and Their Applications in Cancer
title_short	The Role of Exosomes and Their Applications in Cancer
title_full	The Role of Exosomes and Their Applications in Cancer
title_fullStr	The Role of Exosomes and Their Applications in Cancer
title_full_unstemmed	The Role of Exosomes and Their Applications in Cancer
title_sort	role of exosomes and their applications in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a90bea6bb9f4e9da0fe363f93ab957e
work_keys_str_mv	AT yujuzhou theroleofexosomesandtheirapplicationsincancer AT yingzhang theroleofexosomesandtheirapplicationsincancer AT huangong theroleofexosomesandtheirapplicationsincancer AT siqiluo theroleofexosomesandtheirapplicationsincancer AT yancui theroleofexosomesandtheirapplicationsincancer AT yujuzhou roleofexosomesandtheirapplicationsincancer AT yingzhang roleofexosomesandtheirapplicationsincancer AT huangong roleofexosomesandtheirapplicationsincancer AT siqiluo roleofexosomesandtheirapplicationsincancer AT yancui roleofexosomesandtheirapplicationsincancer
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The Role of Exosomes and Their Applications in Cancer

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