The association between MTHFR polymorphism and cervical cancer

Abstract Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical cancer. There were 372 women who per...

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Autores principales:	Jiao-Mei Gong, Yong Shen, Wan-Wan Shan, Yan-Xia He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a93e23ab26b4717808731edb6ba5d6d
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spelling	oai:doaj.org-article:7a93e23ab26b4717808731edb6ba5d6d2021-12-02T12:32:21ZThe association between MTHFR polymorphism and cervical cancer10.1038/s41598-018-25726-92045-2322https://doaj.org/article/7a93e23ab26b4717808731edb6ba5d6d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25726-9https://doaj.org/toc/2045-2322Abstract Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical cancer. There were 372 women who performed genetic and folic acid assessments. For the MTHFR C677T, there was no significant difference in the distribution of C allele and T allele in the three groups. However, the mutant C allele of MTHFR A1298C was significantly higher in the cancer group than in the normal group. Similarly, the mutant G allele of MTRR A66G was also higher than the normal group. The serum folic acid levels were gradually decreased with the development of cervical lesions. Serum folate levels in 4–9 ng/ml and ≤4 ng/ml were both significantly associated with cervical cancer risk. However, the MTHFR C677T polymorphism was not associated with the risk of cervical cancer or CIN. In contrast, the MTHFR A1298C polymorphism could increase the risk of both cervical cancer and CIN. In addition, the MTRR A66G polymorphism was only associated with the risk of cervical cancer but not CIN.Jiao-Mei GongYong ShenWan-Wan ShanYan-Xia HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiao-Mei Gong Yong Shen Wan-Wan Shan Yan-Xia He The association between MTHFR polymorphism and cervical cancer
description	Abstract Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical cancer. There were 372 women who performed genetic and folic acid assessments. For the MTHFR C677T, there was no significant difference in the distribution of C allele and T allele in the three groups. However, the mutant C allele of MTHFR A1298C was significantly higher in the cancer group than in the normal group. Similarly, the mutant G allele of MTRR A66G was also higher than the normal group. The serum folic acid levels were gradually decreased with the development of cervical lesions. Serum folate levels in 4–9 ng/ml and ≤4 ng/ml were both significantly associated with cervical cancer risk. However, the MTHFR C677T polymorphism was not associated with the risk of cervical cancer or CIN. In contrast, the MTHFR A1298C polymorphism could increase the risk of both cervical cancer and CIN. In addition, the MTRR A66G polymorphism was only associated with the risk of cervical cancer but not CIN.
format	article
author	Jiao-Mei Gong Yong Shen Wan-Wan Shan Yan-Xia He
author_facet	Jiao-Mei Gong Yong Shen Wan-Wan Shan Yan-Xia He
author_sort	Jiao-Mei Gong
title	The association between MTHFR polymorphism and cervical cancer
title_short	The association between MTHFR polymorphism and cervical cancer
title_full	The association between MTHFR polymorphism and cervical cancer
title_fullStr	The association between MTHFR polymorphism and cervical cancer
title_full_unstemmed	The association between MTHFR polymorphism and cervical cancer
title_sort	association between mthfr polymorphism and cervical cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7a93e23ab26b4717808731edb6ba5d6d
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_version_	1718394102854189056

The association between MTHFR polymorphism and cervical cancer

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