Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

Wallace C Duncan Jr, Elizabeth E Slonena, Nadia S Hejazi, Nancy Brutsche, Lawrence T Park, Ioline D Henter, Elizabeth D Ballard, Carlos A Zarate Jr Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Purpose: T...

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Autores principales:	Duncan Jr WC, Slonena EE, Hejazi NS, Brutsche N, Park LT, Henter ID, Ballard ED, Zarate Jr CA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	antidepressant ketamine glutamate motor activity sleep deprivation clock-gene Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7a9527ad4ce64ed5a59934b9eeef8c77
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spelling	oai:doaj.org-article:7a9527ad4ce64ed5a59934b9eeef8c772021-12-02T07:32:06ZAre 24-hour motor activity patterns associated with continued rapid response to ketamine?1178-2021https://doaj.org/article/7a9527ad4ce64ed5a59934b9eeef8c772018-10-01T00:00:00Zhttps://www.dovepress.com/are-24-hour-motor-activity-patterns-associated-with-continued-rapid-re-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wallace C Duncan Jr, Elizabeth E Slonena, Nadia S Hejazi, Nancy Brutsche, Lawrence T Park, Ioline D Henter, Elizabeth D Ballard, Carlos A Zarate Jr Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Purpose: This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine.Methods: Twenty-four-hour activity patterns were compared across 5 days of 24-hour activity rhythms in patients with major depressive disorder who displayed either a brief antidepressant response (24–48 hours), a continued antidepressant response (>72 hours), or no antidepressant response to ketamine. These postinfusion-response profiles were then used retrospectively to examine cohort-specific fitted parameters at baseline, postinfusion day 1 (D1), and postinfusion D3.Results: Relative to the nonresponders, the cohort experiencing a brief antidepressant response had blunted 24-hour amplitude that extended from baseline through D3 and postketamine phase advance of activity on D1 that reverted to baseline on D3. Relative to the nonresponders, the cohort experiencing a continued antidepressant response to ketamine had phase-advanced activity at both baseline and D1, as well as increased amplitude on D1 and D3.Conclusion: Taken together, the results suggest that the time course of antidepressant response to ketamine is influenced by underlying biological differences in motor activity timekeeping. These differences may provide clues that link durable mood response with the molecular machinery of the circadian system, thus leading to more effective interventions. In addition, biomarkers of preinfusion motor activity (eg, amplitude, timing) may be useful for recommending future individualized treatment interventions, to the extent that they help identify patients who may relapse quickly after treatment. Keywords: antidepressant, ketamine, glutamate, motor activity, sleep deprivation, clock-geneDuncan Jr WCSlonena EEHejazi NSBrutsche NPark LTHenter IDBallard EDZarate Jr CADove Medical Pressarticleantidepressantketamineglutamatemotor activitysleep deprivationclock-geneNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2739-2748 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidepressant ketamine glutamate motor activity sleep deprivation clock-gene Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	antidepressant ketamine glutamate motor activity sleep deprivation clock-gene Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Duncan Jr WC Slonena EE Hejazi NS Brutsche N Park LT Henter ID Ballard ED Zarate Jr CA Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
description	Wallace C Duncan Jr, Elizabeth E Slonena, Nadia S Hejazi, Nancy Brutsche, Lawrence T Park, Ioline D Henter, Elizabeth D Ballard, Carlos A Zarate Jr Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Purpose: This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine.Methods: Twenty-four-hour activity patterns were compared across 5 days of 24-hour activity rhythms in patients with major depressive disorder who displayed either a brief antidepressant response (24–48 hours), a continued antidepressant response (>72 hours), or no antidepressant response to ketamine. These postinfusion-response profiles were then used retrospectively to examine cohort-specific fitted parameters at baseline, postinfusion day 1 (D1), and postinfusion D3.Results: Relative to the nonresponders, the cohort experiencing a brief antidepressant response had blunted 24-hour amplitude that extended from baseline through D3 and postketamine phase advance of activity on D1 that reverted to baseline on D3. Relative to the nonresponders, the cohort experiencing a continued antidepressant response to ketamine had phase-advanced activity at both baseline and D1, as well as increased amplitude on D1 and D3.Conclusion: Taken together, the results suggest that the time course of antidepressant response to ketamine is influenced by underlying biological differences in motor activity timekeeping. These differences may provide clues that link durable mood response with the molecular machinery of the circadian system, thus leading to more effective interventions. In addition, biomarkers of preinfusion motor activity (eg, amplitude, timing) may be useful for recommending future individualized treatment interventions, to the extent that they help identify patients who may relapse quickly after treatment. Keywords: antidepressant, ketamine, glutamate, motor activity, sleep deprivation, clock-gene
format	article
author	Duncan Jr WC Slonena EE Hejazi NS Brutsche N Park LT Henter ID Ballard ED Zarate Jr CA
author_facet	Duncan Jr WC Slonena EE Hejazi NS Brutsche N Park LT Henter ID Ballard ED Zarate Jr CA
author_sort	Duncan Jr WC
title	Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
title_short	Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
title_full	Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
title_fullStr	Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
title_full_unstemmed	Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
title_sort	are 24-hour motor activity patterns associated with continued rapid response to ketamine?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7a9527ad4ce64ed5a59934b9eeef8c77
work_keys_str_mv	AT duncanjrwc are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT slonenaee are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT hejazins are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT brutschen are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT parklt are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT henterid are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT ballarded are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine AT zaratejrca are24hourmotoractivitypatternsassociatedwithcontinuedrapidresponsetoketamine
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Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

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