What are the causes for low birthweight in Japan? A single hospital-based study.

Low-birthweight (LBW; <2,500 g) babies are at a higher risk of poor educational achievement, disability, and metabolic diseases than normal-birthweight babies in the future. However, reliable data on factors that contribute to LBW have not been considered previously. Therefore, we aimed to examin...

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Autores principales:	Yoshifumi Kasuga, Satoru Ikenoue, Masumi Tamagawa, Maki Oishi, Toyohide Endo, Yu Sato, Miho Iida, Yasunori Sato, Mamoru Tanaka, Daigo Ochiai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a97b9408ab043ab8e156c89ef1f27d7
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spelling	oai:doaj.org-article:7a97b9408ab043ab8e156c89ef1f27d72021-12-02T20:10:11ZWhat are the causes for low birthweight in Japan? A single hospital-based study.1932-620310.1371/journal.pone.0253719https://doaj.org/article/7a97b9408ab043ab8e156c89ef1f27d72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253719https://doaj.org/toc/1932-6203Low-birthweight (LBW; <2,500 g) babies are at a higher risk of poor educational achievement, disability, and metabolic diseases than normal-birthweight babies in the future. However, reliable data on factors that contribute to LBW have not been considered previously. Therefore, we aimed to examine the distribution of the causes for LBW. A retrospective review of cases involving 4,224 babies whose mothers underwent perinatal care at Keio University Hospital between 2013 and 2019 was conducted. The LBW incidence was 24% (1,028 babies). Of the 1,028 LBW babies, 231 babies were from multiple pregnancies. Of the 797 singleton LBW babies, 518 (65%) were born preterm. Obstetric complications in women with preterm LBW babies included premature rupture of membrane or labor onset (31%), hypertensive disorders of pregnancy (HDP, 64%), fetal growth restriction (24%), non-reassuring fetal status (14%), and placental previa/vasa previa (8%). Of the 279 term LBW babies, 109 (39%) were small for gestational age. Multiple logistic regression analyses revealed the following factors as LBW risk factors in term neonates: low pre-pregnancy maternal weight, inadequate gestational weight gain, birth at 37 gestational weeks, HDP, anemia during pregnancy, female sex, and neonatal congenital anomalies. HDP was an LBW risk factor not only in preterm births but also in term births. Our results suggest that both modifiable and non-modifiable factors are causes for LBW. It may be appropriate to consider a heterogeneous rather than a simple classification of LBW and to evaluate future health risks based on contributing factors.Yoshifumi KasugaSatoru IkenoueMasumi TamagawaMaki OishiToyohide EndoYu SatoMiho IidaYasunori SatoMamoru TanakaDaigo OchiaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253719 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshifumi Kasuga Satoru Ikenoue Masumi Tamagawa Maki Oishi Toyohide Endo Yu Sato Miho Iida Yasunori Sato Mamoru Tanaka Daigo Ochiai What are the causes for low birthweight in Japan? A single hospital-based study.
description	Low-birthweight (LBW; <2,500 g) babies are at a higher risk of poor educational achievement, disability, and metabolic diseases than normal-birthweight babies in the future. However, reliable data on factors that contribute to LBW have not been considered previously. Therefore, we aimed to examine the distribution of the causes for LBW. A retrospective review of cases involving 4,224 babies whose mothers underwent perinatal care at Keio University Hospital between 2013 and 2019 was conducted. The LBW incidence was 24% (1,028 babies). Of the 1,028 LBW babies, 231 babies were from multiple pregnancies. Of the 797 singleton LBW babies, 518 (65%) were born preterm. Obstetric complications in women with preterm LBW babies included premature rupture of membrane or labor onset (31%), hypertensive disorders of pregnancy (HDP, 64%), fetal growth restriction (24%), non-reassuring fetal status (14%), and placental previa/vasa previa (8%). Of the 279 term LBW babies, 109 (39%) were small for gestational age. Multiple logistic regression analyses revealed the following factors as LBW risk factors in term neonates: low pre-pregnancy maternal weight, inadequate gestational weight gain, birth at 37 gestational weeks, HDP, anemia during pregnancy, female sex, and neonatal congenital anomalies. HDP was an LBW risk factor not only in preterm births but also in term births. Our results suggest that both modifiable and non-modifiable factors are causes for LBW. It may be appropriate to consider a heterogeneous rather than a simple classification of LBW and to evaluate future health risks based on contributing factors.
format	article
author	Yoshifumi Kasuga Satoru Ikenoue Masumi Tamagawa Maki Oishi Toyohide Endo Yu Sato Miho Iida Yasunori Sato Mamoru Tanaka Daigo Ochiai
author_facet	Yoshifumi Kasuga Satoru Ikenoue Masumi Tamagawa Maki Oishi Toyohide Endo Yu Sato Miho Iida Yasunori Sato Mamoru Tanaka Daigo Ochiai
author_sort	Yoshifumi Kasuga
title	What are the causes for low birthweight in Japan? A single hospital-based study.
title_short	What are the causes for low birthweight in Japan? A single hospital-based study.
title_full	What are the causes for low birthweight in Japan? A single hospital-based study.
title_fullStr	What are the causes for low birthweight in Japan? A single hospital-based study.
title_full_unstemmed	What are the causes for low birthweight in Japan? A single hospital-based study.
title_sort	what are the causes for low birthweight in japan? a single hospital-based study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7a97b9408ab043ab8e156c89ef1f27d7
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What are the causes for low birthweight in Japan? A single hospital-based study.

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