Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

Semaphorin ligands and cognate receptors are important in patterning the vasculature. Here, Aghajanian et al.report an unexpected role for ErbB2 in endothelial cells where it partners with Nrp1 to form a novel semaphoring holoreceptor required for embryonic vascular patterning.

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Autores principales:	Haig Aghajanian, Young Kuk Cho, Lauren J. Manderfield, Madison R. Herling, Mudit Gupta, Vivienne C. Ho, Li Li, Karl Degenhardt, Alla Aharonov, Eldad Tzahor, Jonathan A. Epstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a9d9e43d08b4be2ab4bc5c09ab863dd
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spelling	oai:doaj.org-article:7a9d9e43d08b4be2ab4bc5c09ab863dd2021-12-02T17:32:22ZCoronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor10.1038/ncomms120382041-1723https://doaj.org/article/7a9d9e43d08b4be2ab4bc5c09ab863dd2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12038https://doaj.org/toc/2041-1723Semaphorin ligands and cognate receptors are important in patterning the vasculature. Here, Aghajanian et al.report an unexpected role for ErbB2 in endothelial cells where it partners with Nrp1 to form a novel semaphoring holoreceptor required for embryonic vascular patterning.Haig AghajanianYoung Kuk ChoLauren J. ManderfieldMadison R. HerlingMudit GuptaVivienne C. HoLi LiKarl DegenhardtAlla AharonovEldad TzahorJonathan A. EpsteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haig Aghajanian Young Kuk Cho Lauren J. Manderfield Madison R. Herling Mudit Gupta Vivienne C. Ho Li Li Karl Degenhardt Alla Aharonov Eldad Tzahor Jonathan A. Epstein Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
description	Semaphorin ligands and cognate receptors are important in patterning the vasculature. Here, Aghajanian et al.report an unexpected role for ErbB2 in endothelial cells where it partners with Nrp1 to form a novel semaphoring holoreceptor required for embryonic vascular patterning.
format	article
author	Haig Aghajanian Young Kuk Cho Lauren J. Manderfield Madison R. Herling Mudit Gupta Vivienne C. Ho Li Li Karl Degenhardt Alla Aharonov Eldad Tzahor Jonathan A. Epstein
author_facet	Haig Aghajanian Young Kuk Cho Lauren J. Manderfield Madison R. Herling Mudit Gupta Vivienne C. Ho Li Li Karl Degenhardt Alla Aharonov Eldad Tzahor Jonathan A. Epstein
author_sort	Haig Aghajanian
title	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
title_short	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
title_full	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
title_fullStr	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
title_full_unstemmed	Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
title_sort	coronary vasculature patterning requires a novel endothelial erbb2 holoreceptor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7a9d9e43d08b4be2ab4bc5c09ab863dd
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Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

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