The effect of norepinephrine on common carotid artery blood flow in septic shock patients

Abstract This study was designed to evaluate the hemodynamic effect of norepinephrine (NE) on the peak systolic velocity (PSV), diameter, and blood flow of the common carotid artery (CCA) using the point-of-care ultrasound (POCUS) in patients with septic shock. The study involved patients above 18 y...

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Autores principales:	Seok Goo Kim, Ik Joon Jo, Soo Yeon Kang, Jonghoon Yoo, Guntak Lee, Jong Eun Park, Taerim Kim, Sung Yeon Hwang, Won Chul Cha, Tae Gun Shin, Heewon Han, Hee Yoon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7aa1bc0830a8409c8e58eaba3bceae75
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spelling	oai:doaj.org-article:7aa1bc0830a8409c8e58eaba3bceae752021-12-02T15:10:50ZThe effect of norepinephrine on common carotid artery blood flow in septic shock patients10.1038/s41598-021-96082-42045-2322https://doaj.org/article/7aa1bc0830a8409c8e58eaba3bceae752021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96082-4https://doaj.org/toc/2045-2322Abstract This study was designed to evaluate the hemodynamic effect of norepinephrine (NE) on the peak systolic velocity (PSV), diameter, and blood flow of the common carotid artery (CCA) using the point-of-care ultrasound (POCUS) in patients with septic shock. The study involved patients above 18 years old with septic shock. Arterial monitoring, carotid ultrasonography, and transthoracic echocardiography were performed before NE administration (T0). When the mean arterial pressure exceeded 65 mmHg after NE administration (T1), the measurement was repeated. Twenty-four patients (median age 67 [interquartile range: 54–77] years; 42% female) with septic shock were examined in this study. Before (T0) and after (T1) NE administration, the PSV (mean, standard deviation [SD]) changed from 85.3 (21.1) cm/s to 83.5 (23.5) cm/s (p = 0.417); this change was not significant. However, the diameter and blood flow of the CCA increased significantly from 0.6 (0.09) cm and 0.75 (0.27) L/min to 0.66 (0.09) cm and 0.85 (0.27) L/min, respectively (p < 0.001). The diameter of the left ventricular outflow tract (LVOT) remained unchanged, but the velocity time integral of the LVOT increased significantly from 21.7 (4.39) cm to 23.6 (5.14) cm. There was no significant correlation between changes in blood flow of the CCA and changes in cardiac output (coefficient −0.365, p = 0.079). In conclusion, NE increased the diameter and blood flow of the CCA significantly, without changing the PSV in patients with septic shock.Seok Goo KimIk Joon JoSoo Yeon KangJonghoon YooGuntak LeeJong Eun ParkTaerim KimSung Yeon HwangWon Chul ChaTae Gun ShinHeewon HanHee YoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seok Goo Kim Ik Joon Jo Soo Yeon Kang Jonghoon Yoo Guntak Lee Jong Eun Park Taerim Kim Sung Yeon Hwang Won Chul Cha Tae Gun Shin Heewon Han Hee Yoon The effect of norepinephrine on common carotid artery blood flow in septic shock patients
description	Abstract This study was designed to evaluate the hemodynamic effect of norepinephrine (NE) on the peak systolic velocity (PSV), diameter, and blood flow of the common carotid artery (CCA) using the point-of-care ultrasound (POCUS) in patients with septic shock. The study involved patients above 18 years old with septic shock. Arterial monitoring, carotid ultrasonography, and transthoracic echocardiography were performed before NE administration (T0). When the mean arterial pressure exceeded 65 mmHg after NE administration (T1), the measurement was repeated. Twenty-four patients (median age 67 [interquartile range: 54–77] years; 42% female) with septic shock were examined in this study. Before (T0) and after (T1) NE administration, the PSV (mean, standard deviation [SD]) changed from 85.3 (21.1) cm/s to 83.5 (23.5) cm/s (p = 0.417); this change was not significant. However, the diameter and blood flow of the CCA increased significantly from 0.6 (0.09) cm and 0.75 (0.27) L/min to 0.66 (0.09) cm and 0.85 (0.27) L/min, respectively (p < 0.001). The diameter of the left ventricular outflow tract (LVOT) remained unchanged, but the velocity time integral of the LVOT increased significantly from 21.7 (4.39) cm to 23.6 (5.14) cm. There was no significant correlation between changes in blood flow of the CCA and changes in cardiac output (coefficient −0.365, p = 0.079). In conclusion, NE increased the diameter and blood flow of the CCA significantly, without changing the PSV in patients with septic shock.
format	article
author	Seok Goo Kim Ik Joon Jo Soo Yeon Kang Jonghoon Yoo Guntak Lee Jong Eun Park Taerim Kim Sung Yeon Hwang Won Chul Cha Tae Gun Shin Heewon Han Hee Yoon
author_facet	Seok Goo Kim Ik Joon Jo Soo Yeon Kang Jonghoon Yoo Guntak Lee Jong Eun Park Taerim Kim Sung Yeon Hwang Won Chul Cha Tae Gun Shin Heewon Han Hee Yoon
author_sort	Seok Goo Kim
title	The effect of norepinephrine on common carotid artery blood flow in septic shock patients
title_short	The effect of norepinephrine on common carotid artery blood flow in septic shock patients
title_full	The effect of norepinephrine on common carotid artery blood flow in septic shock patients
title_fullStr	The effect of norepinephrine on common carotid artery blood flow in septic shock patients
title_full_unstemmed	The effect of norepinephrine on common carotid artery blood flow in septic shock patients
title_sort	effect of norepinephrine on common carotid artery blood flow in septic shock patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7aa1bc0830a8409c8e58eaba3bceae75
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The effect of norepinephrine on common carotid artery blood flow in septic shock patients

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