Joint morphogenetic cells in the adult mammalian synovium

The stem cells that maintain and repair adult joint tissues in mammals, including articular cartilage, remain incompletely defined. Here the authors perform lineage tracing studies in adult mice and find an ontogenetically defined progenitor cell population that is functional in the synovial joint a...

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Autores principales: Anke J. Roelofs, Janja Zupan, Anna H. K. Riemen, Karolina Kania, Sharon Ansboro, Nathan White, Susan M. Clark, Cosimo De Bari
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7aa1bdfe37f5443580838119bffe69ec
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Sumario:The stem cells that maintain and repair adult joint tissues in mammals, including articular cartilage, remain incompletely defined. Here the authors perform lineage tracing studies in adult mice and find an ontogenetically defined progenitor cell population that is functional in the synovial joint and distinct from previously reported mesenchymal stem cell populations.