Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in turn cause cells to exhibit low invasiveness.

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Autores principales:	Ching-Wen Lin, Lu-Kai Wang, Shu-Ping Wang, Yih-Leong Chang, Yi-Ying Wu, Hsuan-Yu Chen, Tzu-Hung Hsiao, Wei-Yun Lai, Hsuan-Hsuan Lu, Ya-Hsuan Chang, Shuenn-Chen Yang, Ming-Wei Lin, Chi-Yuan Chen, Tse-Ming Hong, Pan-Chyr Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7aa2a547a6274b01b109ab20da77c6cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7aa2a547a6274b01b109ab20da77c6cb2021-12-02T14:39:33ZDaxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis10.1038/ncomms138672041-1723https://doaj.org/article/7aa2a547a6274b01b109ab20da77c6cb2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13867https://doaj.org/toc/2041-1723Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in turn cause cells to exhibit low invasiveness.Ching-Wen LinLu-Kai WangShu-Ping WangYih-Leong ChangYi-Ying WuHsuan-Yu ChenTzu-Hung HsiaoWei-Yun LaiHsuan-Hsuan LuYa-Hsuan ChangShuenn-Chen YangMing-Wei LinChi-Yuan ChenTse-Ming HongPan-Chyr YangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ching-Wen Lin Lu-Kai Wang Shu-Ping Wang Yih-Leong Chang Yi-Ying Wu Hsuan-Yu Chen Tzu-Hung Hsiao Wei-Yun Lai Hsuan-Hsuan Lu Ya-Hsuan Chang Shuenn-Chen Yang Ming-Wei Lin Chi-Yuan Chen Tse-Ming Hong Pan-Chyr Yang Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
description	Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in turn cause cells to exhibit low invasiveness.
format	article
author	Ching-Wen Lin Lu-Kai Wang Shu-Ping Wang Yih-Leong Chang Yi-Ying Wu Hsuan-Yu Chen Tzu-Hung Hsiao Wei-Yun Lai Hsuan-Hsuan Lu Ya-Hsuan Chang Shuenn-Chen Yang Ming-Wei Lin Chi-Yuan Chen Tse-Ming Hong Pan-Chyr Yang
author_facet	Ching-Wen Lin Lu-Kai Wang Shu-Ping Wang Yih-Leong Chang Yi-Ying Wu Hsuan-Yu Chen Tzu-Hung Hsiao Wei-Yun Lai Hsuan-Hsuan Lu Ya-Hsuan Chang Shuenn-Chen Yang Ming-Wei Lin Chi-Yuan Chen Tse-Ming Hong Pan-Chyr Yang
author_sort	Ching-Wen Lin
title	Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
title_short	Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
title_full	Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
title_fullStr	Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
title_full_unstemmed	Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
title_sort	daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the hif-1α/hdac1/slug axis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7aa2a547a6274b01b109ab20da77c6cb
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Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

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