Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection

Bacteria-induced acute lung infection (ALI) is a severe burden to human health, which could cause acute respiratory distress syndrome (ARDS) and kill the patient rapidly. Therefore, it is of great significance to develop effective nanomedicine and therapeutic approach to eliminate the invading bacte...

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Autores principales:	Ji Luo, Xiaobo Li, Siyuan Dong, Peiyao Zhu, Wenke Liu, Shuguang Zhang, Jiang Du
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	layer-by-layer hybrid np ph-responsive antimicrobial ali Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7aa360d22b49469582f89e6b945d417f
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spelling	oai:doaj.org-article:7aa360d22b49469582f89e6b945d417f2021-11-17T14:21:55ZLayer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection1071-75441521-046410.1080/10717544.2021.2000676https://doaj.org/article/7aa360d22b49469582f89e6b945d417f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/10717544.2021.2000676https://doaj.org/toc/1071-7544https://doaj.org/toc/1521-0464Bacteria-induced acute lung infection (ALI) is a severe burden to human health, which could cause acute respiratory distress syndrome (ARDS) and kill the patient rapidly. Therefore, it is of great significance to develop effective nanomedicine and therapeutic approach to eliminate the invading bacteria in the lung and manage ALI. In this study, we design a layer-by-layer (LbL) liposome-polymer hybrid nanoparticle (HNP) with a pH-triggered drug release profile to deliver antibiotics for the eradication of bacteria to treat ALI. The liposome is prepared by the lipid film hydration method with a homogenous hydrodynamic diameter and low polydispersity index (PDI). The antibiotic spectinomycin is efficiently loaded into the liposomal core through the pH-gradient method. The pH-sensitive polycationic polymer poly(β-amino ester) (PBAE) and polyanionic sodium alginate (NaAIg) layers are decorated on the surface of liposome in sequence via electrostatic interaction, resulting in spectinomycin-loaded layer-by-layer hybrid nanoparticles (denoted as Spe@HNPs) which have reasonable particle size, high stability, prolonged circulation time, and pH-triggered drug release profile. The in vitro results demonstrate that Spe@HNPs can efficiently induce the death of bacteria with low minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus) and drug-resistant MRSA BAA40 strains. The in vivo results reveal that Spe@HNPs can eradicate the invading MRSA BAA40 with improved antimicrobial efficacy and low side-effect for ALI treatment. This study not only reports a promising nanomedicine but also provides an effective method to prepare nanoplatforms for drug delivery and controlled release.Ji LuoXiaobo LiSiyuan DongPeiyao ZhuWenke LiuShuguang ZhangJiang DuTaylor & Francis Grouparticlelayer-by-layerhybrid npph-responsiveantimicrobialaliTherapeutics. PharmacologyRM1-950ENDrug Delivery, Vol 28, Iss 1, Pp 2460-2468 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	layer-by-layer hybrid np ph-responsive antimicrobial ali Therapeutics. Pharmacology RM1-950
spellingShingle	layer-by-layer hybrid np ph-responsive antimicrobial ali Therapeutics. Pharmacology RM1-950 Ji Luo Xiaobo Li Siyuan Dong Peiyao Zhu Wenke Liu Shuguang Zhang Jiang Du Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
description	Bacteria-induced acute lung infection (ALI) is a severe burden to human health, which could cause acute respiratory distress syndrome (ARDS) and kill the patient rapidly. Therefore, it is of great significance to develop effective nanomedicine and therapeutic approach to eliminate the invading bacteria in the lung and manage ALI. In this study, we design a layer-by-layer (LbL) liposome-polymer hybrid nanoparticle (HNP) with a pH-triggered drug release profile to deliver antibiotics for the eradication of bacteria to treat ALI. The liposome is prepared by the lipid film hydration method with a homogenous hydrodynamic diameter and low polydispersity index (PDI). The antibiotic spectinomycin is efficiently loaded into the liposomal core through the pH-gradient method. The pH-sensitive polycationic polymer poly(β-amino ester) (PBAE) and polyanionic sodium alginate (NaAIg) layers are decorated on the surface of liposome in sequence via electrostatic interaction, resulting in spectinomycin-loaded layer-by-layer hybrid nanoparticles (denoted as Spe@HNPs) which have reasonable particle size, high stability, prolonged circulation time, and pH-triggered drug release profile. The in vitro results demonstrate that Spe@HNPs can efficiently induce the death of bacteria with low minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus) and drug-resistant MRSA BAA40 strains. The in vivo results reveal that Spe@HNPs can eradicate the invading MRSA BAA40 with improved antimicrobial efficacy and low side-effect for ALI treatment. This study not only reports a promising nanomedicine but also provides an effective method to prepare nanoplatforms for drug delivery and controlled release.
format	article
author	Ji Luo Xiaobo Li Siyuan Dong Peiyao Zhu Wenke Liu Shuguang Zhang Jiang Du
author_facet	Ji Luo Xiaobo Li Siyuan Dong Peiyao Zhu Wenke Liu Shuguang Zhang Jiang Du
author_sort	Ji Luo
title	Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
title_short	Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
title_full	Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
title_fullStr	Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
title_full_unstemmed	Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection
title_sort	layer-by-layer coated hybrid nanoparticles with ph-sensitivity for drug delivery to treat acute lung infection
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/7aa360d22b49469582f89e6b945d417f
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Layer-by-layer coated hybrid nanoparticles with pH-sensitivity for drug delivery to treat acute lung infection

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