Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.

In breast carcinomas, increased levels of insulin-like growth factor 1 (IGF-1) can act as a mitogen to augment tumorigenesis through the regulation of MAPK and AKT signaling pathways. Signaling through these two pathways allows IGF-1 to employ mechanisms that favor proliferation and cellular surviva...

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Autores principales:	Elizabeth C Martin, Melyssa R Bratton, Yun Zhu, Lyndsay V Rhodes, Syreeta L Tilghman, Bridgette M Collins-Burow, Matthew E Burow
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7aa4bd7ccd8044ce84fe440ce14cba74
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spelling	oai:doaj.org-article:7aa4bd7ccd8044ce84fe440ce14cba742021-11-18T08:06:59ZInsulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.1932-620310.1371/journal.pone.0049067https://doaj.org/article/7aa4bd7ccd8044ce84fe440ce14cba742012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226206/?tool=EBIhttps://doaj.org/toc/1932-6203In breast carcinomas, increased levels of insulin-like growth factor 1 (IGF-1) can act as a mitogen to augment tumorigenesis through the regulation of MAPK and AKT signaling pathways. Signaling through these two pathways allows IGF-1 to employ mechanisms that favor proliferation and cellular survival. Here we demonstrate a subset of previously described tumor suppressor and oncogenic microRNAs (miRNAs) that are under the direct regulation of IGF-1 signaling. Additionally, we show that the selective inhibition of either the MAPK or AKT pathways prior to IGF-1 stimulation prevents the expression of previously described tumor suppressor miRNAs that are family and cluster specific. Here we have defined, for the first time, specific miRNAs under the direct regulation of IGF-1 signaling in the estrogen receptor positive MCF-7 breast cancer cell line and demonstrate kinase signaling as a modulator of expression for a small subset of microRNAs. Taken together, these data give new insights into mechanisms governing IGF-1 signaling in breast cancer.Elizabeth C MartinMelyssa R BrattonYun ZhuLyndsay V RhodesSyreeta L TilghmanBridgette M Collins-BurowMatthew E BurowPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49067 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elizabeth C Martin Melyssa R Bratton Yun Zhu Lyndsay V Rhodes Syreeta L Tilghman Bridgette M Collins-Burow Matthew E Burow Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
description	In breast carcinomas, increased levels of insulin-like growth factor 1 (IGF-1) can act as a mitogen to augment tumorigenesis through the regulation of MAPK and AKT signaling pathways. Signaling through these two pathways allows IGF-1 to employ mechanisms that favor proliferation and cellular survival. Here we demonstrate a subset of previously described tumor suppressor and oncogenic microRNAs (miRNAs) that are under the direct regulation of IGF-1 signaling. Additionally, we show that the selective inhibition of either the MAPK or AKT pathways prior to IGF-1 stimulation prevents the expression of previously described tumor suppressor miRNAs that are family and cluster specific. Here we have defined, for the first time, specific miRNAs under the direct regulation of IGF-1 signaling in the estrogen receptor positive MCF-7 breast cancer cell line and demonstrate kinase signaling as a modulator of expression for a small subset of microRNAs. Taken together, these data give new insights into mechanisms governing IGF-1 signaling in breast cancer.
format	article
author	Elizabeth C Martin Melyssa R Bratton Yun Zhu Lyndsay V Rhodes Syreeta L Tilghman Bridgette M Collins-Burow Matthew E Burow
author_facet	Elizabeth C Martin Melyssa R Bratton Yun Zhu Lyndsay V Rhodes Syreeta L Tilghman Bridgette M Collins-Burow Matthew E Burow
author_sort	Elizabeth C Martin
title	Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
title_short	Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
title_full	Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
title_fullStr	Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
title_full_unstemmed	Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.
title_sort	insulin-like growth factor-1 signaling regulates mirna expression in mcf-7 breast cancer cell line.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7aa4bd7ccd8044ce84fe440ce14cba74
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Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line.

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