Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota

Background: Electromagnetic pollution cannot be ignored. Long-term low-dose electromagnetic field (EMF) exposure can cause central nervous system dysfunction without effective prevention. Materials/Methods: Male C57BL/6J mice (6–8 weeks, 17–20 g) were used in this study. Depression-like and anxiety-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xue Luo, Xueyan Huang, Zhen Luo, Zeze Wang, Genlin He, Yulong Tan, Boyi Zhang, Huan Zhou, Ping Li, Tingting Shen, Xueting Yu, Xuesen Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Heat acclimation Electromagnetic field Depression Gut microbiota Metabolomics analysis Cross-tolerance Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/7aa60bb567c54b1587fa014b0ca26321
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7aa60bb567c54b1587fa014b0ca26321
record_format	dspace
spelling	oai:doaj.org-article:7aa60bb567c54b1587fa014b0ca263212021-11-18T04:43:16ZElectromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota0147-651310.1016/j.ecoenv.2021.112980https://doaj.org/article/7aa60bb567c54b1587fa014b0ca263212021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010927https://doaj.org/toc/0147-6513Background: Electromagnetic pollution cannot be ignored. Long-term low-dose electromagnetic field (EMF) exposure can cause central nervous system dysfunction without effective prevention. Materials/Methods: Male C57BL/6J mice (6–8 weeks, 17–20 g) were used in this study. Depression-like and anxiety-like behaviors detected by behavioral experiments were compared among different treatments. 16S rRNA gene sequencing and non-targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics were used to explore the relationship between EMF exposure and heat acclimation (HA) effects on gut microbes and serum metabolites. Results: Both EMF and HA regulated the proportions of p_Firmicutes and p_Bacteroidota. EMF exposure caused the proportions of 6 kinds of bacteria, such as g_Butyricicoccus and g_Anaerotruncus, to change significantly (p < 0.05). HA restored the balance of gut microbes that was affected by EMF exposure and the proportion of probiotics (g_Lactobacillus) increased significantly (p < 0.01). Serum metabolite analysis suggested that HA alleviated the disturbance of serum metabolites (such as cholesterol and D-mannose) induced by EMF exposure. Both the metabolic KEGG pathways and PICRUSt functional analysis demonstrated that tryptophan metabolism, pyrimidine metabolism and amino acid biosynthesis were involved. Conclusions: EMF exposure not only led to depression-like neurobehavioral disorders, but also to gut microbiota imbalance. HA alleviated the depression features caused by EMF exposure. Based on the analysis of gut microbiota associated with serum metabolites, we speculated that gut microbiota might play a vital role in the cross-tolerance provided by HA.Xue LuoXueyan HuangZhen LuoZeze WangGenlin HeYulong TanBoyi ZhangHuan ZhouPing LiTingting ShenXueting YuXuesen YangElsevierarticleHeat acclimationElectromagnetic fieldDepressionGut microbiotaMetabolomics analysisCross-toleranceEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112980- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heat acclimation Electromagnetic field Depression Gut microbiota Metabolomics analysis Cross-tolerance Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Heat acclimation Electromagnetic field Depression Gut microbiota Metabolomics analysis Cross-tolerance Environmental pollution TD172-193.5 Environmental sciences GE1-350 Xue Luo Xueyan Huang Zhen Luo Zeze Wang Genlin He Yulong Tan Boyi Zhang Huan Zhou Ping Li Tingting Shen Xueting Yu Xuesen Yang Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
description	Background: Electromagnetic pollution cannot be ignored. Long-term low-dose electromagnetic field (EMF) exposure can cause central nervous system dysfunction without effective prevention. Materials/Methods: Male C57BL/6J mice (6–8 weeks, 17–20 g) were used in this study. Depression-like and anxiety-like behaviors detected by behavioral experiments were compared among different treatments. 16S rRNA gene sequencing and non-targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics were used to explore the relationship between EMF exposure and heat acclimation (HA) effects on gut microbes and serum metabolites. Results: Both EMF and HA regulated the proportions of p_Firmicutes and p_Bacteroidota. EMF exposure caused the proportions of 6 kinds of bacteria, such as g_Butyricicoccus and g_Anaerotruncus, to change significantly (p < 0.05). HA restored the balance of gut microbes that was affected by EMF exposure and the proportion of probiotics (g_Lactobacillus) increased significantly (p < 0.01). Serum metabolite analysis suggested that HA alleviated the disturbance of serum metabolites (such as cholesterol and D-mannose) induced by EMF exposure. Both the metabolic KEGG pathways and PICRUSt functional analysis demonstrated that tryptophan metabolism, pyrimidine metabolism and amino acid biosynthesis were involved. Conclusions: EMF exposure not only led to depression-like neurobehavioral disorders, but also to gut microbiota imbalance. HA alleviated the depression features caused by EMF exposure. Based on the analysis of gut microbiota associated with serum metabolites, we speculated that gut microbiota might play a vital role in the cross-tolerance provided by HA.
format	article
author	Xue Luo Xueyan Huang Zhen Luo Zeze Wang Genlin He Yulong Tan Boyi Zhang Huan Zhou Ping Li Tingting Shen Xueting Yu Xuesen Yang
author_facet	Xue Luo Xueyan Huang Zhen Luo Zeze Wang Genlin He Yulong Tan Boyi Zhang Huan Zhou Ping Li Tingting Shen Xueting Yu Xuesen Yang
author_sort	Xue Luo
title	Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
title_short	Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
title_full	Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
title_fullStr	Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
title_full_unstemmed	Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
title_sort	electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7aa60bb567c54b1587fa014b0ca26321
work_keys_str_mv	AT xueluo electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT xueyanhuang electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT zhenluo electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT zezewang electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT genlinhe electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT yulongtan electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT boyizhang electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT huanzhou electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT pingli electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT tingtingshen electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT xuetingyu electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota AT xuesenyang electromagneticfieldexposureinduceddepressionfeaturescouldbealleviatedbyheatacclimationbasedonremodelingthegutmicrobiota
_version_	1718425109851537408

Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota

Ejemplares similares